Cyclin D1、P16及CDK4基因与胃癌相关性的研究进展  

Research Progress of Cyclin D1,P16 and CDK4 in Gastric Cancer

作　　者：宋吉[1] 李玛琳[2] 

机构地区：[1]昆明医科大学天然药物药理重点实验室,云南昆明650500 [2]云南中医学院药学院,云南昆明650500

出　　处：《昆明医科大学学报》2013年第10期148-151,共4页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81060271)

摘　　要：胃癌是全世界发病率和死亡率排名第二位的恶性肿瘤,而我国是世界上胃癌发病率最高的国家之一.细胞周期蛋白的调控能对肿瘤的机制研究及基因治疗提供有效依据.细胞周期中的G1/S期是调控的关键点,其中Cyclin D1、P16及CDK4基因起着重要的作用,且与胃癌之间有着较大的关联性,但上述基因与胃癌之间的关系尚不明确.为了更好地认识Cyclin D1、P16及CDK4基因在胃癌中表达的情况,就近年来相关的研究进行综述.Gastric cancer is a malignant tumor with the second highest incidence and mortality in the world, and China is one of the countries with the highest incidence of gastric cancer in the world. Research on the regulation of cell cycle protein can provide effective evidence for the mechanism of tumor and gene therapy.G1/S phase is the key point for cell cycle regulation,Cyclin D1 and CDK4 gene and P16 play important roles in this phase and have great correlation with gastric cancer,but the exact relationship between these genes and gastric cancer is still unclear. In order to better understand the expression of Cyclin D1 and CDK4 gene and P16 in gastric cancer, the related researches in recent years were summarized in this paper.

关 键 词：CYCLIN D1 P16 CDK4 胃癌 基因治疗 

分 类 号：R735.2[医药卫生—肿瘤]