HCV基因异质性及其宿主基因多态性  

HCV genetic heterogeneity and its host genetics

作　　者：聂永红[1] 许春梅[1] 

机构地区：[1]金昌市疾病预防控制中心,甘肃金昌737100

出　　处：《临床肝胆病杂志》2013年第10期797-800,共4页Journal of Clinical Hepatology

摘　　要：丙型肝炎的进展、严重程度、治疗反应性差异不仅与病毒的遗传多样性有关,而且与宿主IL-28B、IP-10、ITPA基因多态性有关。分别介绍了HCV基因多态性和宿主基因单核苷酸多态性的分子流行病学、临床和治疗学方面的研究进展,提出迫切需要可靠的有关病毒及宿主的相关分子流行病学数据,以协助决策HCV筛检等公共卫生问题,降低丙型肝炎全球发病率和病死率。Hepatitis C represents a major worldwide public health problem. Studies have shown that both genetic diversity of hepatitis C vi-rus （ HCV ） and genetic pnlymorphisms of IL - 28B, ITPA, and IP - 10 in the host are implicated in the progression of hepatitis C, treatment response, and adverse effects. The research advances in the molecular epidemiology and clinical and therapeutic interventions of HCV genet-ic heterogeneity and single nueleotide polymorphisms in its host are reviewed, h is suggested that there is a pressing need for reliable data on the molecular epidemiology of HCV and its host, which will assist in the decision making of public health issues and reduce the morbidity and mortality of hepatitis C worldwide.

关 键 词：肝炎 丙型 肝炎病毒 丙型 遗传异质性 遗传学 

分 类 号：R512.63[医药卫生—内科学]