ERK-1和Cyclin D1在乳腺癌中表达的相关性分析  

Expression and significance of ERK-1and Cyclin D1 of Human breast cancer

作　　者：赵亚男[1] 王蕾[2] 孙冬霞[1] 吴士茜[3] 

机构地区：[1]河北邯郸市妇幼保健院,河北邯郸056001 [2]河北工程大学医学院,河北邯郸056001 [3]河北邯郸市中心医院病理科,河北邯郸056000

出　　处：《中国现代医学杂志》2013年第26期75-78,共4页China Journal of Modern Medicine

摘　　要：目的检测乳腺癌组织中ERK-1和Cyclin D1的表达并探讨其意义。方法采用免疫组织化学SP法检测56例乳腺癌组织、30例乳腺癌旁正常乳腺组织石蜡切片ER K-1和Cyclin D1的表达情况。结果乳腺癌组织中ER K-1和Cyclin D1表达定位于细胞核,其表达率分别为55.36%(31/60)和62.50%(35/60),明显高于乳腺癌旁正常乳腺组织(P<0.05);56例乳腺癌组织中,ERK-1和Cyclin D1蛋白在组织学分级(G3级)及病理分期(Ⅲ期)的表达率分别高于G1+G2级和Ⅰ、Ⅱ期(P<0.05),与肌层浸润程度有关(P<0.05),另外,ERK-1与无淋巴结转移无关(P>0.05),Cyclin D1与无淋巴结转移有关(P<0.05),而与病理组织类型无关(P>0.05);相关性分析显示,二者之间呈正相关(P<0.05)。结论二者在乳腺癌呈高表达,且与乳腺癌的发生、发展和转移密切相关。[Objective] To investigate the expressions of ERK-1 and Cyclin D1 in human breast cancer and discuss their significance. [Methods] The expressions of ERK-1 and Cyclin D1 in the specimens of 56 cases with human breast cancer and 30 cases with nontumor normal breast were used SP immunohistochemistry method. [Results] The expressions of ERK-1 and Cyclin D1 in human breast cancer were located with the nucleus. The positive expression rates were 55.36% （31 / 60） and 62.50% （35/60） respectively which were significantly higher than those in normal tissue （P 〈0.05）. In the breast cancer group, the rate of ERK- 1 and Cyclin D1 expression in the histological grade G3 and pathological stage m were significantly higher than that in GI＋G2 grade and stage Ⅰ ～ Ⅱ （P〈0.05）, and both of them were related with myometrial invasion （P〈0.05）. But they were not related with pathology pattern of organization （P〉0.05）. The expression of ERK-1 and Cyelin D1 in breast cancer group were positively correlated with each other （P〈0.05）. [Conclusion] ERK-1 and Cyclin D1 were highly expressed in the breast cancer and their expressions were related with the occurrence, develooment and the metastasis of the human breast cancer.

关 键 词：乳腺肿瘤 ERK-1 CYCLIN D1 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]