大肠癌组织黏蛋白MUC2和sialyl lewis X联合表达的临床意义  

Clinical significance of MUC2, sialyl lewis X in colorectal neoplasm

作　　者：于秀文[1] 吴甜[1] 王俊苹[1] 

机构地区：[1]黑龙江省齐齐哈尔医学院病理学系,黑龙江齐齐哈尔161006

出　　处：《中国现代医学杂志》2013年第25期20-23,共4页China Journal of Modern Medicine

基　　金：黑龙江省教育厅高等学校青年学术骨干支持计划项目(No:1155G66)

摘　　要：目的探讨大肠腺癌组织粘蛋白MUC2和sialyl lewis X(sLex)的分型与临床各个病理参数之间的关系。方法应用免疫组织化学双染法对34例远切端大肠黏膜、18例大肠腺瘤及55例大肠腺癌组织进行粘蛋白MUC2、sLex检测。结果远切端大肠黏膜、大肠腺瘤及大肠腺癌中,黏蛋白MUC2阳性表达率分别为100%、94.4%和58.2%(P<0.01);sLex阳性表达率分别为5.9%、50.0%和80.0%(P<0.05)。根据MUC2和sLex在大肠腺癌中的表达把大肠腺癌分为四型:MUC2+/sLex+、MUC2+/sLex-、MUC2-/sLex+、MUC2-/sLex-。MUC2+/sLex+型与患者的性别具有相关性;MUC2+/sLex-型与淋巴结转移、Duke’s分期具有相关性;MUC2-/sLex+型与发生部位、分化程度具有相关性;MUC2-/sLex-型与大肠腺癌临床病理参数均不具有相关性。结论 MUC2的下调表达或sLex的上调表达可能参与了大肠肿瘤的发生及恶性转化,各型大肠腺癌不同程度与其分化、生物学行为相关,对临床上判断预后具有较大的意义。[ Objective ] To investigate the relation between the classification of MUC2 and sialyl lewis X （sLex） in colorectal adenocarcinoma and its clinical pathological parameters. [ Methods] 20 specimens of normal colorectal mucosal tissues, 18 specimens of colorectal adenoma and 60 specimens of colorectal adenocarcinoma were examined for the expression of MUC2 and sLex using immunohistochemical double staining. [ Results ] In the above tissue, the positive expression rates of MUC2 were 100.00%, 94.4%, 58.2%（P 〈0.01） respectively, and sLex were 5.9%, 50.0%, 80.0%（P 〈0.01） respectively. Colorectal adenocarcinoma could be classified into four phenotypes： MUC2＋/sLex＋, MUC2＋/sLex-, MUC2-/sLex＋, MUC2-/sLex-. MUC2＋/sLex＋ showed significant correlation with sex. MUC2＋/sLex- showed significant correlation with lymph node spread and Dukes staging survival period. MUC2-/sLex＋ showed significant correlation with site and differentiation. MUC2-/sLexshowed no significance in relation to all the clinical pathological parameters. [ Conclusions ] MUC2 down-regulation or sLex up-regulation may participate in the patho- genesis of colorectal adenocarcinoma. Classification of colorectal adenocarcinoma is relevant to the differentiation, biological behaviour of colorectal adenocarcinoma, which can be used to predict the patients prognosis.

关 键 词：大肠腺癌 MUC2 SIALYL LEWIS X 

分 类 号：R735.34[医药卫生—肿瘤]