HLA-I在乳腺癌组织中的表达及其临床意义  

Clinical Implication on Expression of HLA Class I in Breast Cancer Tissures

作　　者：李林卿[1] 庄文欣[2] 李鹏程[1] 孙学军[1] 

机构地区：[1]中国人民解放军第89医院普外二科,山东潍坊261021 [2]潍坊医学院医学研究实验中心,山东潍坊261053

出　　处：《中国普外基础与临床杂志》2013年第10期1132-1136,共5页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的研究人类白细胞抗原-I类分子(HLA-I)在乳腺癌组织中的表达及其临床意义。方法采用免疫组织化学方法检测271例接受乳腺癌手术患者的乳腺癌组织中HLA-I的表达,并分析HLA-I的表达与乳腺癌临床病理特征及其预后的关系。结果 271例患者中有92例(33.9%)乳腺癌组织中HLA-I呈强阳性表达,而179例(66.1%)的HLA-I表达下调;乳腺癌组织中HLA-I的表达与腋窝淋巴结转移、TNM分期、其他淋巴结转移及血管侵犯均相关(P<0.05)。HLA-I表达阳性患者的无病生存率明显高于HLA-I表达下调者(P<0.05)。结论检测乳腺癌组织中HLA-I的表达情况,对于预测肿瘤进展情况及其预后具有重要意义。Objective To investigate the clinical implication on expression of HLA class I in breast cancer tissures. Methods The expression of HLA class I in 271 patients with breast cancer that underwent radical operation was examined by using immunohistochemically, and the correlation between the expression of HLA class I and clinicalpathological characteristics and prognosis of breast cancer was analyzed. Results The strong positive expression of HLA class I in breast cancer tissures was observed in 92 patients （33.9%）, the expressions of HLA class I in 179 patients （66.1%） were downregulation. The expression of HLA class I expression in breast cancer tissures was significantly associated with the axillary lymph node metastasis, TNM stage （P〈0.05）, other lymph node metastasis, and vascular invasion （P〈0.05）. The disease free survival rate of patients with positive expression of HLA class I was higher than that expression downregulation of HLA class I （P〈0.05）. Conclusion The examination of HLA class I expression is useful for the prediction of tumor progression and recurrent risk of breast cancer via the antitumor immune system.

关 键 词：HLA-I类分子 T细胞免疫 抗癌活性 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]