认知干预训练对轻度认知功能障碍患者认知功能和事件相关电位P300的影响  

The effect of cognitive intervention training on cognitive ability and auditory event related potential P300in patients with mild cognitive impairment

作　　者：何冰[1] 卢国华[1] 杨增云[1] 范静波[1] 张媛媛[1] 张兰娥[1] 张莹莹[1] 

机构地区：[1]山东省潍坊医学院护理学院,261053

出　　处：《中国康复医学杂志》2013年第11期1006-1009,共4页Chinese Journal of Rehabilitation Medicine

基　　金：山东省自然科学基金项目(ZR2010HM042;ZR2011HM002)

摘　　要：目的:探讨认知干预训练对轻度认知功能障碍(MCI)患者认知功能的影响和听觉事件相关电位P300改变的特点。方法:2010年12月至2012年12月从潍坊社区筛选MCI患者50例作为研究对象,随机分为两组,应用简易精神状态量表(MMSE)和事件相关电位P300评估两组受试者训练前后的认知干预效果。结果:干预前两组患者P300潜伏期、波幅及MMSE得分无显著性差异(P>0.05),经过6个月的干预后,干预组P300潜伏期(350.90±15.85)比干预前缩短(P<0.05),与对照组(370.04±21.25)相比明显缩短(P<0.01);波幅(12.01±1.95)与对照组相比增高(P<0.05);MMSE得分(26.19±1.21)比干预前增加(P<0.05),与对照组(24.52±1.34)相比明显增加(P<0.01)。对照组P300潜伏期、波幅及MMSE得分与6个月前相比变化均不明显(P>0.05)。结论:认知训练可以有效延缓认知功能的下降,明显改善MCI患者的认知功能状况。听觉事件相关电位P300测定可以作为对MCI患者干预前后认知功能定量评价的工具。Objective：To discuss the affects of cognitive intervention training on cognitive ability and auditory event relat- ed potential P300 in patients with mild cognitive impairment（MCI）. Method：Patients with MCI were randomly assigned either to cognitive intervention groups, receiving a 6-month cognitive intervention, or control group, receiving no intervention. Mini mental state examination （MMSE） and auditory event related potentials（ERPs） P300 test were administered at baseline and after six-month interven- tion to evaluate the intervention effect. Result：After six months, the P300 latency periods of intervention group（350.90±15.85） were shorter than be- fore （P〈0.05）, and significantly shortened compared with control group （370.04±21.25,P〈0.01）; The amplitude （12.01±1.95） increased comparing with control group （P〈0.05）; the scores of MMSE （26.19±1.21） were higher than before （P 〈 0.05） and significantly higher compared with control group（24.52±1.34） （P 〈 0.01）. The changes of P300 latency, amplitude and MMSE scores were not significant in control group （P〉0.05）. Conclusion：Cognitive training can effectively prolong the decline of cognitive function improve the cognitive function significantly in MCI patients. Auditory ERPs P300 test can be used as a quantitative evaluation tool of cognitive function before and after the intervention for MCI patients

关 键 词：认知干预训练 听觉事件相关电位P300 简易精神状态量表 轻度认知功能障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学]