Fusion genes in solid tumors: an emerging target for cancer diagnosis and treatment  

作　　者：Brittany C.Parker Wei Zhang 

机构地区：[1]Department of Pathology,Unit 85,The University of Texas MD Anderson Cancer Center,Houston,TX 77030,USA [2]The University of Texas Graduate School of Biomedical Sciences,Houston,TX 77030,USA

出　　处：《Chinese Journal of Cancer》2013年第11期594-603,共10页

基　　金：supported in part by the grant from the National Institutes of Health through MD Anderson Cancer Center (No. CA016672)

摘　　要：Studies over the past decades have uncovered fusion genes, a class of oncogenes that provide immense diagnostic and therapeutic advantages because of their tumor-specific expression. Originally associated with hemotologic cancers, fusion genes have recently been discovered in a wide array of solid tumors, including sarcomas, carcinomas, and tumors of the central nervous system. Fusion genes are attractive as both therapeutic targets and diagnostic tools due to their inherent expression in tumor tissue alone. Therefore, the discovery and elucidation of fusion genes in various cancer types may provide more effective therapies in the future for cancer patients.Studies over the past decades have uncovered fusion genes, a class of oncogenes that provide immense diagnostic and therapeutic advantages because of their tumor-specific expression. Originally associated with hemotologic cancers, fusion genes have recently been discovered in a wide array of solid tumors, including sarcomas, carcinomas, and tumors of the central nervous system. Fusion genes are attractive as both therapeutic targets and diagnostic tools due to their inherent expression in tumor tissue alone. Therefore, the discovery and elucidation of fusion genes in various cancer types may provide more effective therapies in the future for cancer patients.

关 键 词：融合基因 癌症患者 治疗性 实体瘤 肿瘤组织 中枢神经系统 诊断工具 特异性表达 

分 类 号：R730.4[医药卫生—肿瘤]