海洋多不饱和脂肪酸DHA抑制肿瘤机制的研究进展  

Research progress in the tumor suppression mechanisms of marine polyunsaturated fatty acids DHA

作　　者：耿丽晶[1] 曲兴源 孙竹萍[1] 耿嘉玲 刘冰[1] 周围[1] 

机构地区：[1]辽宁医学院食品科学与工程学院,辽宁锦州121001

出　　处：《食品工业科技》2013年第22期385-391,共7页Science and Technology of Food Industry

基　　金：辽宁省自然科学基金项目(201102137);辽宁省高等学校杰出青年学者成长计划(LJQ2012073);辽宁省"大学生创新创业训练计划"项目(201210160011);辽宁医学院"奥鸿"大学生科技创新课题(2011D03);辽宁医学院"校长基金"奥鸿博泽基金医药创新基金项目(XZJJ20130101-03)

摘　　要：DHA即二十二碳六烯酸属于海洋多不饱和脂肪酸,其与我们身体健康有密切关系,即是婴幼儿健康成长过程中不可或缺的营养因子,同时对防治心脑血管疾病和抗癌也有很好的功效,DHA还可以抑制细胞增殖、转移,抑制细胞内信号传导途径,诱导其分化、凋亡,改善肿瘤患者的体质,提高患者的存活率,对多种癌细胞发挥抑制效应。n-3PUFAs是具有多种生物学功能的营养素,所以n-3 PUFAs的调节机体免疫作用机制已受到越来越多人的关注。本文综述了DHA的抑癌作用可能机制,比如抑制类花生酸的生物合成、调控信号传导通路、影响转录因子和基因表达、增强脂质过氧化等。DHA or docosahexaenoic acid is one of marine our body health,and it has many physiological function polyunsaturated fatty acids. It was close relation with It is indispensable to healthy growth of infants and young children in the process of nutritional factors,as well as the prevention and treatment of cardiovascular disease and cancer also has very good efficacy. DHA can inhibit cell proliferation, metastasis, inhibiting intracellular signal transduction pathways,inducing differentiation and apoptosis,improving the patient＇s physique,improve survival rates,exert inhibitory effect on a variety of cancer cells, n-3 PUFAs have a variety of biological functions of nutrients,which regulate the body＇s immune function and have been more and more attention. The inhibition cancer functions of DHA was reviewed in this paper,and the controling class arachidic acid biosynthesis and regulation of signaling pathways were mainly recommended,influence of transcription factors and gene expression and enhance the lipid peroxidation were also discussed.

关 键 词：DHA 肿瘤抑制 机制 海洋多不饱和脂肪酸 

分 类 号：TS201.2[轻工技术与工程—食品科学]