侵袭性垂体腺瘤相关原癌基因研究进展  

Rresearch Progress in Proto-oncogene Related Invasive Pituitary Adenoma

作　　者：胡业帅[1] 杨军[1] 马顺昌[1] 

机构地区：[1]首都医科大学附属复兴医院,北京100038

出　　处：《中国肿瘤》2013年第11期897-900,共4页China Cancer

基　　金：首都医科大学附属复兴医院青年科研基金(YQN201204)

摘　　要：垂体腺瘤是单克隆发生的,即由基因突变引起,而侵袭性垂体腺瘤(invasive pituitary adenoma,IPA)恶性程度更高,且难治愈、易复发。对侵袭性垂体腺瘤相关原癌基因的研究有助于揭示其侵袭性,为在基因层面探索及阐明垂体腺瘤侵袭性的分子生物学机制提供新的途径和方法。全文对IPA相关原癌基因的研究进展作一综述。Pituitary adenoma is considered to derive from monoclonal and cause by gene mutation.Invasive pituitary adenoma（IPA） possesses aggressive characteristics with reccur-prone and difficultto-cure. The research of proto-oncogene associated with IPA is helpful to reveal the significance of aggressiveness in IPA,by which the molecular biology mechanism of IPA could be clarified on the basis of gene regulation,and novel methods be provided. In this article,we summarized the research progress in proto-oncogene related IPA.

关 键 词：垂体腺瘤 侵袭性 原癌基因 基因突变 

分 类 号：R739.4[医药卫生—肿瘤]