Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis  

作　　者：Zhihong Chen Songhe Yang Yaqiang He Chengjun Song Yongping Liu 

机构地区：[1]Department of Human Anatomy, Chengde Medical College [2]Department of Biochemistry, Chengde Medical College

出　　处：《Neural Regeneration Research》2013年第19期1756-1764,共9页中国神经再生研究（英文版）

基　　金：sponsored by the Natural Science Foundation of Hebei Province,H2012406018,H2013406096;a grant from Hebei Province Department of Education,No.2006301

摘　　要：Previous studies have shown that sericin extracted from silk cocoon significantly reduces blood glucose levels and protects the nervous system against diabetes mellitus. In this study, a rat type 2 diabetes mellitus model was established by intraperitoneal injection of 25 mg/kg streptozotocin for 3 successive days, following which the rats were treated with sericin for 35 days. After treatment, the blood glucose levels of the diabetic rats decreased significantly, the growth hormone level in serum and its expression in the hippocampus decreased significantly, while the insulin-like growth factor-1 level in serum and insulin-like growth factor-1 and growth hormone receptor expression in the hippocampus increased significantly. The experimental findings indicate that sericin improves disorders of the growth hormone/insulin-like growth factor 1 axis to alleviate hippocampal damage in diabetic rats.Previous studies have shown that sericin extracted from silk cocoon significantly reduces blood glucose levels and protects the nervous system against diabetes mellitus. In this study, a rat type 2 diabetes mellitus model was established by intraperitoneal injection of 25 mg/kg streptozotocin for 3 successive days, following which the rats were treated with sericin for 35 days. After treatment, the blood glucose levels of the diabetic rats decreased significantly, the growth hormone level in serum and its expression in the hippocampus decreased significantly, while the insulin-like growth factor-1 level in serum and insulin-like growth factor-1 and growth hormone receptor expression in the hippocampus increased significantly. The experimental findings indicate that sericin improves disorders of the growth hormone/insulin-like growth factor 1 axis to alleviate hippocampal damage in diabetic rats.

关 键 词：neural regeneration traditional Chinese medicine SERICIN type 2 diabetes mellitus hippocampus growth hormone insulin-like growth factor 1 growth hormone receptor growth hormone/insulin-likegrowth factor 1 axis STREPTOZOTOCIN blood glucose western blot assay reverse transcription-PCR grants-supported paper NEUROREGENERATION 

分 类 号：R587.1[医药卫生—内分泌]