新疆维吾尔族与汉族非小细胞肺癌EGFR突变和HER2过表达的差异及相关性  

Difference and correlation of EGFR mutations and HER2 overexpression in Uygur and Han' s non-small cell lung cancer in Xinjiang China

作　　者：申红丽[1,2] 张峤[1] 单莉[1] 

机构地区：[1]新疆医科大学附属肿瘤医院内一科,新疆乌鲁木齐830011 [2]新疆建设兵团农六师医院,新疆五家渠831300

出　　处：《现代肿瘤医学》2013年第12期2723-2726,共4页Journal of Modern Oncology

摘　　要：目的:探讨新疆维吾尔族、汉族非小细胞肺癌(NSCLC)人类表皮生长因子受体1(EGFR)突变及人类表皮生长因子受体2(HER2)表达的民族差异性及相关性。方法:采用EGFR突变检测试剂盒对43例汉族、37例维吾尔族NSCLC石蜡切片标本进行EGFR检测,采用PicTureTM试剂二步法检测NSCLC组织中HER2的表达,分别统计两组中二者表达相关性及民族差异性。结果:维吾尔族NSCLC组中EGFR基因突变率10.8%,汉族NSCLC组中EGFR基因突变率44.2%,存在统计学意义(P<0.05),维吾尔族NSCLC组中HER2过表达率21.6%,汉族NSCLC组中HER2过表达率39.5%,无统计学意义(P>0.05),汉族EGFR基因突变与HER2过表达存在正相关(r=0.43)。结论:EGFR及HER2都参与了非小细胞肺癌的发生发展,但不同民族非小细胞肺癌EGFR基因突变存在差异性。Objective：To investigate ethnic differences and correlation of EGFR and HER2 of non - small cell lung cancer in the Uighur nationality and HaM patients in Xinjiang region. Methods ： Forty three cases of the HaM and 37 cases of Uighur non - small cell lung cancer paraffin specimens were firstly detected by human EGFR gene muta- tion detection kits, then tested the expression of HER2 by PicTureTM immunohistochemical reagents. Results：EGFR gene mutation rate was 10.8 % in the Uighur group and 44.2% in HaM group, there was significantly difference （P 〈 0.05）. HER2 ＇s overexpression - rate in Uighur group was 21.6% and 39.5% in the HaM group （ P 〉 0.05 ）. There was a positive correlation between EGFR mutations and HER2 over expression in HaM with the correlation coefficient （ r =0. 43 ）. Conclusion： EGFR and HER2 involved in the development of non - small cell lung cancer. There is sig- nificant difference of EGFR mutations between Uygur and Han＇s non - small cell lung cancer in Xinjiang region.

关 键 词：非小细胞肺癌 EGFR HER2 

分 类 号：R734.2[医药卫生—肿瘤]