1988～1992年中国非综合征性唇腭裂发生率的动态变化  

DYNAMIC VARIATION OF INCIDENCE OF NONSYNDROMIC CLEFT LIP WITH OR WITHOUT CLEFT PALATE DURING 1988 TO 1992 IN CHINA

作　　者：梁娟[1] 王艳萍[1] 周光萱[1] 朱军[1] 缪蕾[1] 吴艳乔[1] 肖坤则[1] 

机构地区：[1]华西医科大学中国出生缺陷监测中心,610041

出　　处：《口腔颌面外科杂志》2000年第4期299-301,共3页Journal of Oral and Maxillofacial Surgery

摘　　要：目的　了解我国 1988～ 1992年非综合征性唇腭裂发生率的动态变化趋势及流行病学特征。方法　采用以医院为单位的整群抽样方法 ,对 1988～ 1992年期间我国 5 0 0多所医院孕 2 8周至产后 7天的 3 2 46 40 8例围产儿 ,4349例非综合征性唇腭裂病例进行回顾性分析。结果　我国 5年非综合征性唇腭裂发生率无显著性差异 ,城乡发生率也无显著性差异。男性发生率为 14.9/万 ,女性发生率为 11.7/万 ,差异有显著性 ,非综合征性唇腭裂的性别比为 1.3∶ 1。三类非综合征性唇腭裂各自的发生率为 :CL± P:7.8/万 ,CL:3.8/万 ,CP:1.8/万。结论　我国非综合征性唇腭裂发生率无变化趋势 ,城乡无差异。男性高于女性 ,唇裂合并腭裂为最常见类型。Objective To study the variation of trend in the incidence and epidemiological characteristics of nonsyndromic cleft lip with or without cleft palate during the period from 1988 to 1992. Methods From 1988 to 1992, data were collected from more than 500 hospital-based units involved in a monitoring program and were analyzed by the National Center for Birth Defects Monitoring. The monitored subjects were the hospitalized births from 28 weeks gestation to a period within 7 days after delivery. Results The variation in the incidence of nonsyndromic cleft lip with or without cleft palate was not significant, and the difference between urban and rural areas not too. The incidence is as high as 14.9/10 000 in males and 11.7/10 000 in females with significant difference. The male/female sex ratio for case was 1.3. The incidences of three types of nonsyndromic cleft lip with or without cleft palate were 7.8/10 000,3.8/10 000,1.8/10 000 respectively for cleft lip with cleft palate, cleft lip alone and cleft palate only. Conclusion There is no variation in the trend of nonsyndromic cleft lip with or without cleft palate in China during the period from 1988 to 1992 and no significant difference bwtween urban and rural areas. The incidence is higher in males than that in females. The most common type is the cleft lip with cleft palate.

关 键 词：唇腭裂 非综合征性 动态变化 中国 

分 类 号：R782.2[医药卫生—口腔医学]