双相障碍不同亚型伴与不伴焦虑障碍的神经心理功能损害的研究  

Differences in neuropsychological functions impairment between subtypes of bipolar disorder with or without co-morbid anxiety disorders

作　　者：吴向平 周韦华[2] 

机构地区：[1]宁波市康宁医院精神科,315201 [2]浙江大学医学院附属第一医院精神科

出　　处：《浙江医学》2013年第21期1917-1920,共4页Zhejiang Medical Journal

摘　　要：目的研究双相障碍不同亚型伴有焦虑障碍与不伴焦虑障碍患者临床表现、心理社会功能损害及治疗效果的差异。方法本研究将95例双相障碍患者根据其自身发病特点分成双相Ⅰ型不伴有焦虑障碍组(28例),双相Ⅰ型伴有焦虑障碍组(26例),双相Ⅱ型不伴有焦虑障碍组(20例),双相Ⅱ型伴有焦虑障碍组(21例)。同时将健康体检者作为对照组(30例),各组均实施韦氏记忆测验、注意测验及执行功能等神经心理学测验。结果双相Ⅰ型伴有焦虑障碍组仅在工作记忆方面较不伴焦虑障碍组差,两组在注意及执行功能方面均低于对照组,但两者间的差异无统计学意义;双相Ⅱ型伴有焦虑障碍组在视觉即刻记忆、视觉延迟回忆、工作记忆和精神运动速度方面较不伴焦虑障碍组差。结论双相Ⅱ型伴焦虑障碍的患者在神经心理功能损害方面较双相Ⅰ型伴有焦虑障碍患者更加严重。Objective To investigate the differences of clinical features between subtypes of bipolar disorder （BP） with or without co- morbid anxiety disorders （ADs）. Methods Ninety- five BP patients were classified into 4 groups： BP- I without AD （n=28）, BP- I with AD（n=26）, BP- II without AD（n=20） and BP- II with AD（n=21）;and 30 healthy subjects（HC） served as controls. Neuropsychological tests were performed in al patients and controls. Results The neuropsychological score of BP- I with AD patients was lower than that of BP- I without patients only in working memory. The neuropsychological scores in visual immediate memory, visual delayed memory, working memory, and psychomotor speed of BP- II with AD patients were significantly lower than those of BP- II without AD patients. Conclusion Our investigation indicates that co- morbid AD would damage the neu-ropsychological performance in BP- II patients more severely than those in BP- I patients.

关 键 词：双相障碍 焦虑障碍 神经心理测验 损害 

分 类 号：R749.4[医药卫生—神经病学与精神病学]