心肺复苏家兔血浆ET、CGRP含量变化的研究  

Alteration of contents of endothelialine and calcitonin gene related-peptide in hematoplasma of rabbits during cardio-pulmonary resuscitation

作　　者：李正斌[1] 孙宗立[1] 王学廷[1] 岳玉桃[1] 王建刚[1] 王宏道 徐建莉 

机构地区：[1]洛阳医学高等专科学校附属医院,471003

出　　处：《中国急救医学》2000年第12期701-702,共2页Chinese Journal of Critical Care Medicine

基　　金：河南省自然科学基金资助项目

摘　　要：目的　研究血浆内皮素 (ET)与降钙素基因相关肽 (CGRP)在心脏骤停缺血 /再灌注损伤前后含量变化规律及意义。方法　制作家兔心脏骤停缺血 /再灌注模型 ,观察心肺复苏后各时相血浆ET、CGRP、血压及心电变化。结果　动物在心脏骤停及复苏即刻血浆ET含量明显变化 (P <0 0 5 ) ,而血浆CGRP水平降低 (P <0 0 5 ) ,复苏后 0 5小时血浆ET明显升高(P <0 0 1) ,复苏后 2小时血浆ET、CGRP均较复苏前有明显上升 (P <0 0 5 )。结论　在心脏骤停缺血 /再灌注损伤过程中ET。Objective To probe into the alterative law and significance of contents of endothelialine and calcitonin gene related-peptide in hematoplasma before and after of ischemia reperfusion lesion of sudden cardiac arrest of rabbits.Methods Ischemia reperfusion lesion of sudden cardiac arrest of contents of endothelialine,calcitonin gene related-peptide,blood pressure,and electrocardiogram after cardio-pulmonary resuscitation.Results During sudden cardiac arrest and the just after cardio-pulmonary resuscitation,endothelialine in plasma has no obvious changes( P <0 05),but calcitonin gene related-peptide was decreased( P <0.05),and at 0.5 h after resuscitation,endothelialine began to increase( P <0.01).Compared with before resuscitation,at 2 h after resuscitation,both endothelialine and calcitonin gene related-peptide was obviously increased( P <0.05).Conclusions During ischemia reperfusion lesion of sudden cardiac arrest of rabbits,alteration and relationship of contents of endothelialine and calcitonin gene related-peptide in hematoplasma of rabbits could be an regulating mechanism and they can play an important role during pathophysiological duration.

关 键 词：心肺复苏 内皮素 降钙素基因相关肽 家兔 

分 类 号：R605.974[医药卫生—急诊医学]