Angiogenin gene polymorphism A risk factor for diabetic peripheral neuropathy in the northern Chinese Han population?  

作　　者：Hongli Wang Dongsheng Fan Yingshuang Zhang 

机构地区：[1]Department of Neurology, Peking University Third Hospital

出　　处：《Neural Regeneration Research》2013年第36期3434-3440,共7页中国神经再生研究（英文版）

基　　金：financially sponsored by the Natural Science Foundation of Beijing,No.7102161

摘　　要：Angiogenin is associated with the pathogenesis of diabetic peripheral neuropathy. Here, we se- quenced the coding region of the angiogenin gene in genomic DNA from 207 patients with type 2 diabetes mellitus （129 diabetic peripheral neuropathy patients and 78 diabetic non-neuropathy pa- tients） and 268 healthy controls. All subjects were from the Han population of northern China. No mutations were found. We then compared the genotype and allele frequencies of the angiogenin synonymous single nucleotide polymorphism rs11701 between the diabetic peripheral neuropathy patients and controls, and between the diabetic neuropathy and non-neuropathy patients, using a case-control design. We detected no statistically significant genetic associations. Angiogenin may not be associated with genetic susceptibility to diabetic peripheral neuropathy in the Han population of northern China.Angiogenin is associated with the pathogenesis of diabetic peripheral neuropathy. Here, we se- quenced the coding region of the angiogenin gene in genomic DNA from 207 patients with type 2 diabetes mellitus （129 diabetic peripheral neuropathy patients and 78 diabetic non-neuropathy pa- tients） and 268 healthy controls. All subjects were from the Han population of northern China. No mutations were found. We then compared the genotype and allele frequencies of the angiogenin synonymous single nucleotide polymorphism rs11701 between the diabetic peripheral neuropathy patients and controls, and between the diabetic neuropathy and non-neuropathy patients, using a case-control design. We detected no statistically significant genetic associations. Angiogenin may not be associated with genetic susceptibility to diabetic peripheral neuropathy in the Han population of northern China.

关 键 词：neural regeneration ANGIOGENIN single nucleotide polymorphism type 2 diabetes mellitus diabetic peripheral neuropathy ANGIOGENESIS diabetic microvascular complications genetic susceptibility risk factor peripheral nerve injury grants-supported paper NEUROREGENERATION 

分 类 号：R587.2[医药卫生—内分泌]