高强度超声对兔肝肿瘤营养血管损伤作用的染料灌注和病理观察  

The Effect of HIU on the Rabbit Liver Carcinoma Observed with the X-ray Digital Subtract Angiography and Pathology

作　　者：关利铭[1] 胡凯[1] 李祟雁 李燕 文爽[1] 王智彪[1] 

机构地区：[1]重庆医科大学医学超声工程研究所,重庆400016

出　　处：《中国医学影像技术》2000年第12期1102-1104,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家"95"重点科技攻关项目!资助 (9690 5 0 2 0 1)

摘　　要：目的　观察高强度超声 (HIU)对肿瘤营养血管的破坏作用 ,此作用对抑制肿瘤的增生和转移 ,促使肿瘤良性化有重要意义。方法　采用肝肿瘤血管染料灌注和病理检察相结合的方法 ,观察HIU对兔VX2 肝脏肿瘤营养血管破坏的情况。结果　HIU治疗后 ,血管染料灌注不再充盈 ,病理学方法显示肿瘤营养血管和肿瘤组织发生凝固性坏死。结论　HIFU可能较完全破坏肿瘤营养血管 ,防止血管再生 ,从而有可能抑制肿瘤的再生和转移 ,促使肿瘤良性化。Objective To evaluate the damage effect of high intensity ulstrasound (HIU) on carcinoma vascularities,the effet is important for HIU to inhibitit tumor growth and metastases and make it become benign being. Methods The animal models of the VX 2 tumor in the rabbit liver was setup,compared with histological examination,hepatic carcinoma vascularities dye perfusion was observed. Results After HIU treatment,hepatic carcinoma vascularities dye perfusion was decreased or was not found Histological examination indicated HIU makes carcinoma vascularities with whole tumor tissue coagulative necrosis. Conclusion HIU may damage carcinoma vascularities thoroughly,in such way it may inhibit tumor growth and metastases,which makes tumor return benign form. [

关 键 词：高强度超声 染料灌注 肿瘤血管 肝肿瘤 病理 

分 类 号：R735.7[医药卫生—肿瘤]