The β-alanyl-monoamine synthase ebony is regulated by schizophrenia susceptibility gene dysbindin in Drosophila  

作　　者：LU BinYan SHAO LiSha FENG ShanXi WANG Tian ZHONG Yi 

机构地区：[1]School of Life Sciences, Tsinghua University [2]Tsinghua-Peking Center for Life Sciences, Tsinghua University [3]Cold Spring Harbor Laboratory,Cold Spring Harbor, NY 11724, USA

出　　处：《Science China(Life Sciences)》2014年第1期46-51,共6页中国科学（生命科学英文版）

基　　金：supported by the National Basic Research Program of Ministry of Science and Technology of China(2009CB941301 and 2013CB835102);the Tsinghua University Initiative Scientific Research Program(20111080956,all to Zhong Yi);the China Postdoctoral Science Foundation(2012M510412);supported by the Postdoctoral Fellowship at Tsinghua-Peking Center for Life Sciences

摘　　要：The Drosophila homolog of schizophrenia susceptibility gene dysbindin(Ddysb)affects a range of behaviors through regulation of multiple neurotransmitter signals,including dopamine activity.To gain insights into mechanisms underlying Ddysb-dependent regulation of dopamine signal,we investigated interaction between Ddysb and Ebony,the Drosophilaβ-alanyl-monoamine synthase involved in dopamine recycling.We found that Ddysb was capable of regulating expression of Ebony in a bi-directional manner and its subcellular distribution.Such regulation is confined to glial cells.The expression level of ebony and its accumulation in glial soma depend positively on Ddysb activity,whereas its distribution in glial processes is bound to be reduced in response to any alterations of Ddysb from the normal control level,either an increase or decrease.An optimal binding ratio between Dysb and Ebony might contribute to such non-linear effects.Thus,Ddysb-dependent regulation of Ebony could be one of the mechanisms that mediate dopamine signal.The Drosophila homolog of schizophrenia susceptibility gene dysbindin （Ddysb） affects a range of behaviors through regula- tion of multiple neurotransmitter signals, including dopamine activity. To gain insights into mechanisms underlying Ddysb-dependent regulation of dopamine signal, we investigated interaction between Ddysb and Ebony, the Drosophila β-alanyl-monoamine synthase involved in dopamine recycling. We found that Ddysb was capable of regulating expression of Ebony in a bi-directional manner and its subcellular distribution. Such regulation is confined to glial cells. The expression level of ebony and its accumulation in glial soma depend positively on Ddysb activity, whereas its distribution in glial processes is bound to be reduced in response to any alterations of Ddysb from the normal control level, either an increase or decrease. An optimal binding ratio between Dysb and Ebony might contribute to such non-linear effects. Thus, Ddysb-dependent regulation of Ebony could be one of the mechanisms that mediate dopamine signal.

关 键 词：DYSBINDIN ebony glial cell subcellular distribution DOPAMINE 

分 类 号：R749.3[医药卫生—神经病学与精神病学]