短串联重复序列基因座Penta D和Penta E与主动攻击行为的关联研究  

Association between the initiative-aggressive behaviors and the short tandem repeats loci Penta D and Penta E

作　　者：杨春 巴华杰[2] 余海鹰 赵汉清 过伟 高志勤 

机构地区：[1]解放军第一0二医精院神科,常州213003 [2]常州市公安局刑警支队DNA实验室

出　　处：《中华精神科杂志》2014年第1期39-43,共5页Chinese Journal of Psychiatry

基　　金：2013年南京军区医学科技创新课题（MS016）

摘　　要：目的探讨主动攻击行为与相关短串联重复序列（short tandem repeats，STR）基因座PentaD、PentaE的关联情况。方法运用PowerPlex16HSSystem荧光标记复合扩增体系对307例主动攻击行为罪犯（研究组）与459名非攻击行为健康个体（对照组）样本进行PCR复合扩增，然后应用美国AB13130XL型基因分析系统对扩增产物进行电泳和基因检测，观察2组PentaD、PentaE基因座等位基因及基因型频率的差异。结果Penta D、PentaE基因座均符合遗传平衡定律（Hardy—Weinberg定律；均P〉0．05）；2组PentaD、PentaE基因座等位基因及基因型频率分布差异有统计学意义（等位基因：P=0．0000，P=0．0013；基因型：P=0．0012，P=0．0000）；单因素分析显示，2组在PentaD基因座等位基因5、6和PentaE基因座等位基因9的频率分布差异均有统计学意义（P=0．0024，P=0．0016，P=0．0021），OR值分别为0．113（95％CI：0．015～0．869）、12．092（95％CI：1．506～96．924）、0．225（95％CI：0．078～0．648）。结论PentaD和PentaE基因座多态性与主动攻击行为的发生可能相关联；PentaD基因座的等位基因6可能为主动攻击行为发生的易感因素，PentaD基因座的等位基因5和PentaE基因座的等位基因9可能为主动攻击行为发生的抗性因素。Objective To investigate the relationship of the initiative-aggressive behaviors and short tandem repeats （STRs） loci Penta D and Penta E. Methods The biological samples of 307 initiative-aggressive violent offenders and 459 healthy persons without violent behavior were collected. Then all of the sample were amplified by PowerPlex 16 HS System and separated by eleetrophoresis to compare the genotypes and alleles frequency of Penta D and Penta E in both groups. Results Penta D and Penta E loci in both groups were found to coincide with Hardy-Weinberg equilibrium （ P 〉 0. 05 ）. There were significant difference of alleles and genotypes frequency at loci Penta D and Penta E between both groups （ alleles ： P = 0. 000 0, P = 0. 001 3 ; genotypes ： P = 0. 001 2 ; P = 0. 000 0 ） . Univarite analysis showed significant differences at allelle 5, 6 on Penta D and allelle 9 on Penta E between both groups （ P = 0. 002 4, P = 0. 001 6, P = 0. 002 1 ） , with the OR values being 0. 113 （ 95 % CI： 0. 015 - 0. 869 ） , 12. 092 （ 95 % CI： 1. 506 - 96. 924） ,0. 225 （ 95 % CI： 0. 078-0. 648 ） , respectively. Conclusion Penta D and Penta E might be associated with initiative-aggressive behavior, with allelle 6 on Penta D being the susceptible factor and allelle 5 on Penta D and a11elle 9 on Penta E might being the protective factors.

关 键 词：主动攻击型人格障碍 微卫星重复 多态现象 遗传 病例对照研究 

分 类 号：R749.99[医药卫生—神经病学与精神病学]