Hyposmia: a possible biomarker of Parkinson's disease  

作　　者：Qian Xiao Sheng Chen Weidong Le 

机构地区：[1]Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine [2]Institutes of Translational Medicine, 1st Affiliated Hospital of Dalian Medical Universtiy

出　　处：《Neuroscience Bulletin》2014年第1期134-140,共7页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(81370470 and 81171201);National Basic Research Development Program of China 2011CB510003)

摘　　要：Hyposmia, identified as reduced sensitivity to odor, is a common non-motor symptom of Parkinson＇s disease （PD） that antedates the typical motor symptoms by several years. It occurs in -90% of early-stage cases of PD. In addition to the high prevalence, the occurrence of hyposmia may also predict a higher risk of PD. Investigations into hyposmia and its relationship with PD may help elucidate the underlying pathogenic mechanisms. This review provides an update of olfactory dysfunction in PD and its potential as a biomarker for this devastating disease.Hyposmia, identified as reduced sensitivity to odor, is a common non-motor symptom of Parkinson＇s disease （PD） that antedates the typical motor symptoms by several years. It occurs in -90% of early-stage cases of PD. In addition to the high prevalence, the occurrence of hyposmia may also predict a higher risk of PD. Investigations into hyposmia and its relationship with PD may help elucidate the underlying pathogenic mechanisms. This review provides an update of olfactory dysfunction in PD and its potential as a biomarker for this devastating disease.

关 键 词：HYPOSMIA Parkinson＇s disease OLFACTION BIOMARKER 

分 类 号：R742.5[医药卫生—神经病学与精神病学]