毛豆对2型糖尿病小鼠血糖及血脂影响  

Effects of edamame on blood glucose and blood lipid in type 2 diabetic mellitus mice

作　　者：王洲婷 刘璐璐[1] 李佳琪[1] 丁传波[1] 李慧萍[1] 郑毅男[1] 刘文丛[1] 

机构地区：[1]吉林农业大学中药材学院,吉林长春130118

出　　处：《食品工业科技》2014年第4期334-337,共4页Science and Technology of Food Industry

基　　金：吉林省科技发展计划(20110904;20120910)

摘　　要：目的:研究毛豆对链脲菌素致ICR糖尿病小鼠血糖、血脂的影响。方法:高脂饲料联合腹腔注射链脲菌素得到2型糖尿病模型小鼠,以二甲双胍作为阳性对照组,给药组分别为毛豆高剂量组4.35g/kg,毛豆低剂量组2.20g/kg进行28d灌胃实验。结果:给药28d后,毛豆低剂量组血糖降低作用明显,小鼠空腹血糖比实验前降低29.78%,曲线下面积(AUC)下降了12.52%;与模型对照组相比,TC、TG值都有显著降低(p<0.05)。结论:毛豆对2型糖尿病小鼠具有良好的降血糖、降血脂作用。Objective.To study the effect of edamame on blood glucose and blood lipids in （streptozotocin（STZ） -induced ICR diabetic mice. Methods： Models of type 2 diabetes mellitus （T20M） mice） were induced by high fat chow and intraperitoneal injection of streptozotocin （STZ） ,and were divided into different groups, which were given High dose of 4.35g/kg Edamame, low dose of 2.20g/kg Edamame and metformin respectively. Results： After 28d drug administration, symptoms of diabetic mice fed a dose of 2.20g/kg edamame were alleviated obviously. the level of blood glucose in this group decreased by 29.78% and the area under the curve （AUC） decreased by 12.52%. Compared with the model group, the levels of TC and TG in this group were lowered remarkably （p 〈0.05）. Conclusion： Edamame might be related to improving hypoglycemic and hypolipidemic effect in type 2 diabetic mellitus mice.

关 键 词：毛豆 糖尿病 ICR小鼠 血糖 血脂 

分 类 号：TS201.2[轻工技术与工程—食品科学]