特发性弱精子症患者精子中TCTE3的表达  

Expression of TCTE3 in spermatozoa of idiopathic asthenozoospermic patients

作　　者：李玉山[1] 吉晓菲[1] 王全先[1] 杨险峰[1] 潘周辉[1] 胡耀龙[1] 

机构地区：[1]郑州大学第三附属医院人类精子库,郑州450052

出　　处：《郑州大学学报（医学版）》2014年第1期83-85,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：郑州市科技攻关计划项目2010S0828

摘　　要：目的:探讨T复合体相关睾丸表达3(TCTE3)与特发性弱精子症发生的关系。方法:采用RT-PCR和Western blot方法检测正常成年男性(正常对照)和特发性弱精子症患者各30例精子标本中TCTE3 mRNA和蛋白的表达。结果:TCTE3 mRNA和蛋白在特发性弱精子症组精子中的相对表达量均低于正常对照组(t=3.038和2.460,P=0.005和0.017)。结论:TCTE3表达的降低可能在弱精子症的发生中起着重要作用。Aim：To explore the relationship of T-complex associated testis expressed 3（TCTE3） with idiopathic asthe-nozoospermia .Methods：The mRNA and protein expressions of TCTE 3 in 30 cases of normal adult male and 30 cases of idi-opathic asthenozoospermia semen samples were detected by using RT-PCR and Western blot .Results：The relative expres-sion levels of TCTE3 mRNA and protein in the idiopathic asthenozoospermia group were significantly lower than those in the normal control group（t=3.038 and 2.460,P=0.005 and 0.017）.Conclusion： The reduced expression of TCTE3 may play an important role in the incidence of idiopathic asthenozoospermia .

关 键 词：T复合体相关睾丸表达3 特发性弱精子症 轴丝动力蛋白 T-COMPLEX associated TESTIS EXPRESSED 3 

分 类 号：R698.2[医药卫生—泌尿科学]