鬼臼脂素C-环不同结构类型对抗肿瘤活性的影响  

The Effects of Podophyllotoxin Analogues with Different Structures of Ring C on Antitumour Activities

作　　者：何勇[1] 马维勇[1] 陈秀华[1] 张椿年[1] 

机构地区：[1]上海医药工业研究院,上海200040

出　　处：《中国药物化学杂志》2001年第1期9-12,共4页Chinese Journal of Medicinal Chemistry

摘　　要：合成了鬼臼脂素C环 4 位羟基不同取向、C环芳构化、C环反式和非反式稠合、C环 2 ,3 不饱和、C环 3 位引入溴原子等不同结构类型的化合物 ,并测试了其体外抑制KB细胞和L12 10白血病细胞活性。C环结构类型不同 。Podophyllotoxin analogues with different structures of ring C were synthesized.Their activities against L1210 and KB cells were tested.The structure activity relationships were discussed.The different structures of ring C can make differences in cytotoxities.

关 键 词：鬼臼脂素 鬼臼脂素衍生物 构效关系 抗肿瘤 

分 类 号：R914[医药卫生—药物化学]