TNF-α-308基因多态性与强迫症的易感性研究  

The association of TNF-α-308 gene polymorphism and obsessive compulsive disorder

作　　者：高玉峰 邱海棠[2] 王帆[3] 张向阳[3] 傅一笑[2] 罗庆华[2] 杜莲[2] 邱田[2] 蒙华庆[2] 

机构地区：[1]广东省中山市第三人民医院二科,528451 [2]重庆医科大学附属第一医院心理卫生中心,400016 [3]北京回龙观医院中心实验室,100096

出　　处：《重庆医学》2014年第4期396-398,共3页Chongqing medicine

摘　　要：目的探讨TNF-α-308基因多态性与强迫症(OCD)易感性的关系。方法收集26例OCD患者及14例健康对照者的血液,提取DNA后采用聚合酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)法测定TNF-α-308位点的基因多态性,进行各组间基因型分布和等位基因频率的χ2检验,比较各组间基因型分布的差异。计算等位基因的OR值和95%CI,以确定基因多态性与OCD易感性的关系。结果 OCD组及健康对照组均以TNF1/1占优势,OCD组为16.7%(TNF1/2)和83.3%(TNF1/1),而健康对照组中全为TNF1/1型。两组之间的基因型频率分布的比较,差异有统计学意义(χ2=15.73,P<0.01)。OCD组与健康对照组的差异主要来自G等位基因,差异有统计学意义(P<0.01),使其患OCD的危险性提高了1.93倍。结论 TNF-α-308基因多态性可能与OCD的易感性相关。Objective The purpose of this study was to investigate the relationship between TNF-α-308 gene polymorphisms and susceptibility to obsessive-compulsive disorder（OCD） .Methods DNA samples with OCD were collected from 26 severe OCD pa-tients and 14 control ones .The TNF-α-308 gene polymorphisms were analyzed with PCR-RFLP .The data were analyzed by χ2 test . Results Majority the gene type of OCD and the controls are TNF1/1 .The OCD are16 .7% （TNF1/2） ,83 .3% （TNF1/1） ,and all of the controls are TNF1/1 ,the difference are significant（χ2 =15 .73 ,P〈0 .01） .The difference between OCD and controls is from the gene G ,which make the risk of OCD more than controls 1 .93 .Conclusion The TNF-α-308 gene polymorphism probably has associ-ation with OCD .

关 键 词：肿瘤坏死因子Α 强迫症 基因多态性 疾病易感性 

分 类 号：R749.7[医药卫生—神经病学与精神病学]