真菌毒素与角膜真菌感染  

Mycotoxins and fungal infection of cornea

作　　者：吴福进[1] 胡建章[1] 韩晓丽[1] 

机构地区：[1]福建医科大学附属第一医院眼科,福州350000

出　　处：《国际眼科纵览》2013年第6期400-403,共4页International Review of Ophthalmology

基　　金：国家自然科学基金项目（81270976）

摘　　要：真菌毒素（Mycotoxin）是由产毒真菌在适宜的环境条件下产生的具有毒性的次级代谢产物,主要毒性有致癌作用、遗传毒性、致畸作用、肝细胞毒性和免疫抑制等.真菌感染角膜后可能释放真菌毒素导致角膜损害,但至今对真菌毒素在真菌性角膜炎中究竟扮演什么角色,仍不明确.真菌毒素的生物合成受到一系列相关功能基因的调控;此外,pH值、碳氮比等环境条件也能影响其产量.本文就常见的真菌毒素的危害、调控因素及其可能在真菌性角膜炎发生发展中的作用进行综述.Mycotoxins are secondary metabolites produced by the toxigenic fungi in suitable environmental conditions,the main toxicity of which are carcinogenesis,genotoxicity,teratogenesis,hepatotoxicity and immunosuppression.After fungal infects the cornea,it may release mycotoxins to cause corneal damage.However what roles do the mycotoxins play in fungal keratitis is still unclear.The biosynthesis of mycotoxinis is regulated by a series of related function genes ; in addition,pH value,carbon nitrogen ratio and other environmental conditions are the influence factors as well.This article reviews the common harms,regulatory factors and their possible roles in the occurrence and development of keratomycosis.

关 键 词：真菌毒素 真菌性角膜炎 

分 类 号：R772.2[医药卫生—眼科]