妊娠期血浆CRH、E_2及P与早产关系的研究  

Study on the relationships between the plasma CRH, E_2 and P during pregnancy and premature delivery

作　　者：罗穗豫[1,2] 王瑜[1,2] 

机构地区：[1]郑州大学人民医院 [2]河南省人民医院妇产科,450003

出　　处：《中国实用医药》2013年第36期6-8,共3页China Practical Medicine

摘　　要：目的：探讨促肾上腺激素释放激素（corticotropin releasing hormone, CRH）、雌二醇（estradiol, E2）及孕激素（progesterone, P）在妊娠期间的浓度变化及其在早产中的预测作用。方法选取正常妊娠组孕妇54例,先兆早产组孕妇54例,采集外周静脉血分离血浆,用免疫化学发光法测定E2、P,放射免疫法测定CRH水平。结果①正常妊娠血CRH均值28～33周组与＆gt;37周组比,明显低于＆gt;37周组,经t检验P〈0.05；血E2各组间均值经t检验P〉0.05,差异无统计学意义；血P各组均值,28～33周组明显高于＆gt;37周组,经t检验P〈0.05,差异有统计学意义,其余各组差异无统计学意义。②正常妊娠组和先兆早产组在妊娠28～33周血CRH分别为（68.23＆#177;13.34）ng/L和（298.42＆#177;162.78）ng/L；在34～36周分别为（132.75＆#177;126.3） ng/L和（354.42＆#177;50.46） ng/L,经t检验, P值均＆lt;0.05,差异有统计学意义。正常妊娠组和先兆早产组血E2在28～33周分别为（128.72＆#177;50.83）μg/L和（152.94＆#177;31.7）μg/L；在34～36周分别为（136.24＆#177;62.41）μg/L和（173.58＆#177;92.3）μg/L,两组均值经t检验, P值均＆lt;0.05,差异无统计学意义。正常妊娠组和先兆早产组血P在28～33周分别为（523.52＆#177;105.43）μg/L和（353.21＆#177;52.21）μg/L,34～36周（483.24＆#177;113.52）μg/L和（310.25＆#177;83.02）μg/L,差异有统计学意义。结论血P在妊娠晚期各孕周组间变化较为明显,妊娠＆gt;37周之后明显下降。妊娠晚期正常妊娠组中的血浆CRH值随着孕周增加而逐渐升高,而血E2值无明显变化。Objective To discuss the concentration changes of Corticotropin Releasing Hormone（CRH）, Estradiol （E2）, and Progesterone （P） during the third trimester and analyze its predictive role in preterm. Methods 54 pregnant women of threatened prematurity were enrolled as the threatened prematurity group, 54 normal pregnant women were selected as normal pregnant group. Three milliliters of venous blood were taken from all of the women. The levels of E2, P were detected by chemiluminescence immunoassay （CLIA）, CRH by radioimmunoassay （RIA）. Results The mean plasma CRH of 28~33 weeks group was significantly lower than＆gt;37 weeks group in the normal pregnant group （P＆lt;0.05）. There was no significant deference in each groups about the E2 （P＆gt;0.05）. The mean plasma P of 28~33 weeks group was significantly higher than＆gt;37 weeks group （P＆lt;0.05）. In 28~33 weeks the plasma CRH were respectively （68.23＆#177;13.34）ng/L and （298.42＆#177;162.78 ） ng/L in the group of normal pregnant and the group of threatened prematurity. The same as （132.75＆#177;126.3） ng/L and （354.42＆#177;50.46） ng/L in 34~36 weeks. There was a significant difference in the plasma CRH in the two groups （P＆lt;0.05）. In 28~33 weeks the plasma CRH were respectively （68.23＆#177;13.34）ng/L and （298.42＆#177;162.78 ） ngl/L in the group of normal pregnant and the group of threatened prematurity. The same as （132.75＆#177;126.3） ng/L and （354.42＆#177;50.46） ng/L in 34-36 weeks. There was a significant difference in the plasma CRH in the two groups （P＆lt;0.05）. In 28~33 weeks the plasma E2 were respectively （128.72＆#177;50.83）μg/L and （152.94＆#177;31.7）μg/L in the group of normal pregnant and the group of threatened prematurity. The same as （136.24＆#177;62.41）μg/L and （173.58＆#177;92.3）μg/L in 34~36 weeks. There was no significant difference in the plasma E2 in the two groups（P＆gt;0.05）. In 28-33 weeks the plasma P were respectivel

关 键 词：促肾上腺皮质激素释放激素 雌二醇 孕酮 早产 CORTICOTROPIN releasing hormone (CRH) ESTRADIOL (E2) PROGESTERONE (P) 

分 类 号：R714.21[医药卫生—妇产科学]