supported by grants from the National Natural Science Foundation of China(82090033,82288101,U20A6005,32200801,and 32200967);China Postdoctoral Science Foundation(2021M700851,2023T160117,and 2023M740708).
The nucleus accumbens(NAc)plays an important role in various emotional and motivational behaviors that rely on heightened wakefulness.However,the neural mechanisms underlying the relationship between arousal and emoti...
supported by the National Natural Science Foundation of China,Nos.81671387(to YNQ),81701375(to HQD);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),China.
Corticotropin-releasing hormone is a critical component of the hypothalamic–pituitary–adrenal axis,which plays a major role in the body’s immune response to stress.Mast cells are both sensors and effectors in the i...
Hypothalamic Corticotropin-releasing factor (CRF) directly activates the hypothalamic pituitary adrenal axis (HPA axis) during the surgical trauma induced stress response. Electroacupuncture (EA) has been demonstrated...
Supported by National Natural Science Foundation of China,No.81473506;Natural Science Foundation of Zhejiang Province,No.LY13H030011 and No.LY17H290009;State Administration of Traditional Chinese Medicine of Zhejiang Province,No.2013ZB050;Department of Zhejiang Province to Build Funded Project,No.WKJ-ZJ-1531;Zhejiang TCM Science and Technology Project,No.2016ZB047,No.2017ZA056 and No.2018ZB046
AIM To explore the significance of corticotropin-releasing hormone(CRH)-receptor(R)2 in mucosal healing of dextran sulfate sodium(DSS)-induced colitis and the effect of Tong-Xie-Yao-Fang(TXYF) on CRH-R2 expression and...
The activities of corticotropin-releasing factor(CRF) and related peptides are mediated a number of receptors with seven transmembrane domains that are coupled to the Gs and Gq proteins. These receptors are known as C...
Supported by China Postdoctoral Science Foundation funded project,No.200801260,No.20080430117;the National Basic Research Program of China 973 program,No.2009CB522900;the Specialized Research Fund for the Doctoral Program of Higher Education No.20123107110008
AIM: To investigate the effect of electroacupuncture on corticotropin-releasing hormone(CRH) in the colon, spinal cord, and hypothalamus of rats with chronic visceral hypersensitivity.METHODS: A rat model of chronic v...
Supported by Natural Science Foundation of China,No.81070308/H0308
AIM: To explore the role of nesfatin-1 on irritable bowel syndrome (IBS)-like visceral hypersensitivity. METHODS: The animal model of IBS-like visceral hypersensitivity was induced by intracolonic infusion of 0.5% ace...
Supported by The National Institute of Diabetes and Digestive and Kidney Diseases R01 grant DK-57238;Center Grant DK-41301 (Clinical core);Veteran Administration Research Career Scientist Award (YT);NIH DK-78676 (MM)
AIM: To assess corticotropin-releasing factor receptor 2 (CRF 2 ) expression in the colon of healthy subjects and patients with ulcerative colitis (UC). METHODS: We examined CRF2 gene and protein expression in the dis...
Rat models of adjuvant arthritis were established, and anti-corticotropin release hormone serum injection in the lateral ventricles and electroacupuncture at right Jiaji (EX-B2) were performed. The pain threshold wa...