INTRACEREBROVENTRICULAR

作品数：21被引量：57H指数：4
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相关领域：医药卫生更多>>
相关作者：张永平张霄瑜房娟芝杨俐萍钱红更多>>
相关机构：广东海洋大学遵义医学院更多>>
相关期刊：《Neuroscience Bulletin》《Acta Biochimica et Biophysica Sinica》《Journal of Animal Science and Biotechnology》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家教育部博士点基金广东省自然科学基金河北省自然科学基金更多>>
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Neurobehavioral Analysis of Ethanolic Extract of Roots and Rhizomes of Acorus calamus in 6-hydroxydopamine Hydrobromide-induced ADHD Neonatal Rat Model——An Observational Study
《World Journal of Traditional Chinese Medicine》2024年第3期316-321,共6页Mariyappan Kousalya Palayyan Muralidharan Hanish Singh Jayasingh Chellammal 
Background: An imbalance in Nor-adrenaline and Dopamine neurotransmitter levels in the brain is the reason for the development of Attention Deficit Hyperactivity Disorder(ADHD) which is a neurodevelopmental disorder. ...
关键词：6-Hydroxy dopamine INTRACEREBROVENTRICULAR anxiety cognitive HYPERACTIVITY 
Extension of the Lifespan of a Mouse Model of Rett Syndrome by Intracerebroventricular Delivery of MECP2
《Neuroscience Bulletin》2023年第2期297-302,共6页Kan Yang Cheng Cheng Yiting Yuan Yuefang Zhang Shifang Shan Zilong Qiu 
supported by grants from the Youth Innovation Promotion Association Chinese Academy of Sciences(2022269);the Youth Science Fund of State Key Laboratory of Neuroscience(SKLN-2022B006);the National Natural Science Foundation of China(82001211,81941015,82021001);the CPSF-CAS Joint Foundation for Excellent Postdoctoral Fellows(2017LH036);the China Postdoctoral Science Foundation(2017M620173);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDBS01060200);the Program of Shanghai Academic Research Leader,the Open Large Infrastructure Research of Chinese Academy of Sciences,the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the Guangdong Key Scientific and Technological Project(2018B030335001).
DearEditors,Rett Syndrome(RTT)is a severe neurodevelopmental disorder characterized by neural dysfunctions and a reduced lifespan,mainly in female patients,involving loss-of-function mutations in the methyl-CpG bindin...
关键词：MECP2 EXTENSION NEURAL 
Treatment of glutaric aciduria type I(GA-I)via intracerebroventricular delivery of GCDH
《Fundamental Research》2022年第6期836-842,共7页Lu Guo Zhikun Li Yuhuan Li Bin Qu Guanyi Jiao Chen Liang Zongbao Lu Xin-Ge Wang Cheng Huang Hongwei Du Jianmin Liang Qi Zhou Wei Li 
the National Key Research and Development Program(2019YFA0110800 and 2020YFA0707900 to W.L.,and 2018YFA0108400 and 2019YFA0903800 to Q.Z.);Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030403 to W.L.);National Natural Science Foundation of China(31621004 to Q.Z.and W.L.);CAS Project for Young Scientists in Basic Research(YSBR-012 to W.L.).
Glutaric aciduria type I(GA-I)is an autosomal recessive genetic disorder caused by a deficiency in glutaryl-CoA dehydrogenase(GCDH).Patients who do not receive proper treatment may die from acute encephalopathic crisi...
关键词：Glutaric aciduria type I(GA-I) Glutaryl-CoA dehydrogenase(GCDH) Adeno-associated virus(AAV) Gene therapy Neurometabolic disease 
Adenylate cyclase activator forskolin alleviates intracerebroventricular propionic acid-induced mitochondrial dysfunction of autistic rats被引量：1
《Neural Regeneration Research》2020年第6期1140-1149,共10页Sidharth Mehan Saloni Rahi Aarti Tiwari Tarun Kapoor Kajal Rajdev Ramit Sharma Himanshi Khera Sourabh Kosey Umesh Kukkar Rajesh Dudi 
Neuronal mitochondrial dysfunction increases inflammatory mediators and leads to free radical generation and anti-oxidant enzymatic alterations,which are major neuropathological hallmarks responsible for autism.Mitoch...
关键词：ADENYLATE CYCLASE ATP AUTISM FORSKOLIN mitochondrial dysfunction neuroinflammation oxidative stress propionic acid 
Atsttrin reduces lipopolysaccharide-induced neuroinflammation by inhibiting the nuclear factor kappa B signaling pathway被引量：3
《Neural Regeneration Research》2019年第11期1994-2002,共9页Lian Liu Yuan Qu Yi Liu Hua Zhao He-Cheng Ma Ahmed Fayyaz Noor Chang-Jiao Ji Lin Nie Meng Si Lei Cheng 
supported by the National Natural Science Foundation of China,No.81572191(to LC)and 81601067(to HZ)
Progranulin is closely related to neuronal survival in a neuroinflammatory mouse model and attenuates inflammatory reactions. Atsttrin is an engineered protein composed of three progranulin fragments and has been show...
关键词：nerve REGENERATION progranulin Atsttrin NEUROINFLAMMATION inflammatory cytokines LIPOPOLYSACCHARIDE INTRACEREBROVENTRICULAR injection astrocyte nuclear factor kappa B signaling pathway progranulin KNOCKOUT mouse CEREBROSPINAL fluid neural REGENERATION 
S6B-3 Intracerebroventricular Streptozocin-Induced Alzheimer’s Disease-Like Sleep Disorders:Role of the GABAergic System in the Parabrachial Complex
《神经药理学报》2018年第4期96-97,共2页CUI Su-ying SONG Jin-zhi CUI Xiang-yu HU Xiao DING Hui YE Hui ZHANG Yong-he 
Aim:Sleep disorders are common in Alzheimer’s disease(AD)and assumed to directly influence cognitive function and progression of the disease.The present study evaluated sleep characteristics in a rat model of AD that...
关键词：Alzheimer’s disease Sleep DISORDERS GABA STREPTOZOCIN Parabrachial nucleus 
Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3β被引量：9
《Acta Biochimica et Biophysica Sinica》2017年第8期722-728,共7页Fen Lu Xu Li Wei Li Ke Wei Yong Yao Qianlin Zhang Xinliang Liang Jiewen Zhang 
Brain dysfunction, especially cognitive impairment, is one of the main complications in Alzheimer＇s disease （AD）, which threatens the health of 46.8 million people worldwide. At present, the pathogenesis of cogniti...
关键词：TETRAMETHYLPYRAZINE memory impairment GSK-3Β cholinergic neuron 
A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis被引量：4
《Neural Regeneration Research》2014年第11期1145-1153,共9页Xiqing Chai Weina Kong Lingyun Liu Wenguo Yu Zhenqing Zhang Yimin Sun 
supported by the National Natural Science Foundation of China,No.81273983;the Natural Science Foundation of Hebei Province of China,No.C2010001471;the Scientific Research Fund of Hebei Provincial Education Department in China,No.Q2012036
Hypoxia-inducible factor 1 （HIF-1） attenuates amyloid-beta protein neurotoxicity and decreases apoptosis induced by oxidative stress or hypoxia in cortical neurons. In this study, we construct-ed a recombinant adeno...
关键词：nerve regeneration Alzheimer＇s disease adeno-associated virus hypoxia-inducible fac-tor 1~ apoptosis gene therapy calcium concentration TRANSDUCTION intracerebroventricular injec-tion NSFC grant neural regeneration 
Intracerebroventricular opiate infusion for refractory head and facial pain
《World Journal of Clinical Cases》2014年第8期351-356,共6页Darrin J Lee Gene G Gurkoff Amir Goodarzi J Paul Muizelaar James E Boggan Kiarash Shahlaie 
AIM: To study the risks and benefits of intracerebroventricular(ICV) opiate pumps for the management of benign head and face pain.METHODS: SSix patients with refractory trigeminal neuralgia and/or cluster headaches we...
关键词：INTRACEREBROVENTRICULAR OPIATE TRIGEMINAL NEURALGIA Cluster HEADACHE Pain 
Role of nesfatin-1 in a rat model of visceral hypersensitivity被引量：10
《World Journal of Gastroenterology》2013年第22期3487-3493,共7页Fang-Yuan Jia Xue-Liang Li Tian-Nv Li Jing Wu Bi-Yun Xie Lin Lin 
Supported by Natural Science Foundation of China,No.81070308/H0308
AIM: To explore the role of nesfatin-1 on irritable bowel syndrome (IBS)-like visceral hypersensitivity. METHODS: The animal model of IBS-like visceral hypersensitivity was induced by intracolonic infusion of 0.5% ace...
关键词：IRRITABLE bowel syndrome NESFATIN-1 VISCERAL HYPERSENSITIVITY CORTICOTROPIN releasing factor INTRACEREBROVENTRICULAR injection 
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