CYCLASE

作品数：38被引量：49H指数：5
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相关作者：王伟石青朱平程克棣马丽更多>>
相关机构：中国医学科学院北京协和医学院仲恺农业工程学院河北工程大学复旦大学更多>>
相关期刊：《职业与健康》《Synthetic and Systems Biotechnology》《Natural Products and Bioprospecting》《Engineering Microbiology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家级大学生创新创业训练计划更多>>
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Functional characterization of triterpene synthases in Cibotium barometz
《Synthetic and Systems Biotechnology》2023年第3期437-444,共8页Zhongju Ji Baolian Fan Yidu Chen Jingyang Yue Jiabo Chen Rongrong Zhang Yi Tong Zhongqiu Liu Jincai Liang Lixin Duan 
the National Natural Science Foundation of China(No.81874333);the Key Laboratory of Guangdong Drug Administration(2021ZDB03);the Guangdong Basic and Applied Basic Research Foundation(No.2020B1515130005).
Cibotium barometz(Linn.)J.Sm.,a tree fern in the Dicksoniaceae family,is an economically important industrial exported plant in China and widely used in Traditional Chinese Medicine.C.barometz produces a range of bioa...
关键词：2 3-oxidosqualene cyclase Squalene cyclase Cibotium barometz Triterpene biosynthesis 
Cellular response toβ-amyloid neurotoxicity in Alzheimer's disease and implications in new therapeutics被引量：1
《Animal Models and Experimental Medicine》2023年第1期3-9,共7页Haolin Zhang Xianghua Li Xiaoli Wang Jiayu Xu Felice Elefant Juan Wang 
National Institute of Neurological Disorders and Stroke,Grant/Award Number:2RF1NS095799;National Natural Science Foundation of China,Grant/Award Number:31970044 and 91854115;Beijing University of Technology Faculty of Environment and Life Seed Funding,Grant/Award Number:049000513202。
β-Amyloid(Aβ)is a specific pathological hallmark of Alzheimer's disease(AD).Because of its neurotoxicity,AD patients exhibit multiple brain dysfunctions.Disease-modifying therapy(DMT)is the central concept in the de...
关键词：Alzheimer's disease(AD) astrocytes ENDOPEPTIDASE glutaminyl cyclase(QC) microglia p75 neurotrophin receptor(p75NTR) proteolysis targeting chimeras(PROTACs) β-Amyloid(Aβ) 
Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate
《Engineering Microbiology》2022年第3期59-61,共3页Dan Hu 
This work was financially supported by grants from National Key Research and Development Program of China(2018YFA0903200,2018YFA0903201);the National Natural Science Foundation of China(32170060,31870032).
Triterpenes are derived from squalene or oxidosqualene.However,a new class of triterpenes derived from hexaprenyl pyrophosphate has been recently discovered,formed by a new family of chimeric class I triterpene syntha...
关键词：BIOSYNTHESIS Non-squalene triterpenes Terpene cyclase Cyclization mechanisms 
Crystal structure of the polyketide cyclase from Mycobacterium tuberculosis
《Acta Biochimica et Biophysica Sinica》2022年第4期474-481,共8页Jie Zhuang Shihui Fan Chenyun Guo Liubin Feng Huilin Wang Donghai Lin Xinli Liao 
the grants from the National Key Research and Development Project of China(No.2016YFA0500600)。
About 40%of proteins are classified as conserved hypothetical proteins in Mycobacterium tuberculosis(TB).Identification and characterization of these proteins are beneficial to understand the pathogenesis of TB and ex...
关键词：MtPC crystal structure Mycobacterium tuberculosis NMR dynamics NTF2-like superfamily protein 
Adenylate cyclase activator forskolin alleviates intracerebroventricular propionic acid-induced mitochondrial dysfunction of autistic rats被引量：1
《Neural Regeneration Research》2020年第6期1140-1149,共10页Sidharth Mehan Saloni Rahi Aarti Tiwari Tarun Kapoor Kajal Rajdev Ramit Sharma Himanshi Khera Sourabh Kosey Umesh Kukkar Rajesh Dudi 
Neuronal mitochondrial dysfunction increases inflammatory mediators and leads to free radical generation and anti-oxidant enzymatic alterations,which are major neuropathological hallmarks responsible for autism.Mitoch...
关键词：ADENYLATE CYCLASE ATP AUTISM FORSKOLIN mitochondrial dysfunction neuroinflammation oxidative stress propionic acid 
Overexpression of the diguanylate cyclase CdgD blocks developmental transitions and antibiotic biosynthesis in Streptomyces coelicolor被引量：2
《Science China(Life Sciences)》2019年第11期1492-1505,共14页Xiaocao Liu Guosong Zheng Gang Wang Weihong Jiang Lei Li Yinhua Lu 
supported by the National Natural Science Foundation of China (31630003, 31570072 and 31770088);the Science and Technology Commission of Shanghai Municipality (18ZR1446700);the National Science and Technology Major Project (2017ZX09101003-006-012)
Cyclic dimeric GMP(c-di-GMP)has emerged as the nucleotide second messenger regulating both development and antibiotic production in high-GC,Gram-positive streptomycetes.Here,a diguanylate cyclase(DGC),CdgD,encoded by ...
关键词：STREPTOMYCES C-DI-GMP diguanylate CYCLASE CdgD morphological differentiation antibiotic BIOSYNTHESIS 
Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis被引量：3
《Cell Research》2019年第6期502-505,共4页Zhiqiang Wu Linjun Weng Tengbo Zhang Hongling Tian Lan Fang Hongqi Teng Wen Zhang Jing Gao Yun Hao Yaxu Li Hu Zhou Ping Wang 
the National Natural Science Foundation of China (81625019, 31830053, 31871398, 31801177, 31500735, 31801178, 31800757);the Science Technology Commission of Shanghai Municipality (16JC1404500, 18410722000);the Commission of Health and Family Planning of Shanghai Municipality (2017BR014 to P.W.;2017YQ068 to L.F.);the Young Elite Scientist Sponsorship Program by CAST(YESS)(2018QNRC001);the Shanghai Sailing Program (18YF1419500,18YF1419300);the Fundamental Research Funds For the Central Universities (22120170259, 22120180043, 22120180045, 22120180049).
Dear Editor,Cancer cells often upregulate the expression of ligands for the inhibitory immune checkpoints receptor to escape anti-tumor immunity1. Targeting inhibitory immune checkpoints has become one of the most pro...
关键词：AXIS expression SIRP ESCAPE Editor most has EAT 
The allosteric modulation effects of doxycycline, minocycline, and their derivatives on the neuropeptide receptor PAC1-R被引量：2
《Acta Biochimica et Biophysica Sinica》2019年第6期627-637,共11页Suqin Song Like Wang Junfeng Li Xiaoling Huang Rongjie Yu 
This work was supported by the grants from the National Natural Science Foundation of China (Nos.31100545 and 31670848);the Natural Science Foundation of Guangdong Province (No.2016A030313087).
Class B G-protein coupled receptors (GPCR) PAC1-R is a neuropeptide pituitary adenylate cyclase activating polypeptide(PACAP)-preferring receptor that mediates the effective neuroprotective activity.Based on our previ...
关键词：pituitary ADENYLATE cyclase-activating polypeptide G-PROTEIN coupled RECEPTOR PAC1-R allosteric modulator DOXYCYCLINE MINOCYCLINE N-terminal extra cellular domain 
Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models被引量：6
《World Journal of Gastroenterology》2018年第17期1888-1900,共13页Illona-Marie Boulete Anusha Thadi Catherine Beaufrand Viren Patwa Apoorva Joshi John A Foss E Priya Eddy Helene Eutamene Vaseem A Palejwala Vassilia Theodorou Kunwar Shailubhai 
Supported by Synergy Pharmaceuticals Inc.,which provided the funding and the plecanatide,dolcanatide and placebo used for these studies
AIM To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability, integrity of tight junctions and on suppression of visceral hypersensitivity. METHODS Transport of fluorescein...
关键词：Plecanatide Guanylyl cyclase-C AGONISTS Dolcanatide UROGUANYLIN PRECLINICAL cyclic GUANOSINE MONOPHOSPHATE Constipation Inflammatory bowel diseases 
Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders被引量：3
《Neural Regeneration Research》2017年第2期290-300,共11页Sidharth Mehan Shaba Parveen Sanjeev Kalra 
Long term suppression of succinate dehydrogenase by selective inhibitor 3-nitropropionic acid has been used in rodents to model Huntington＇s disease where mitochondrial dysfunction and oxidative damages are primary p...
关键词：nerve regeneration Huntington＇s disease mitochondria adenyl cyclase forskolin oxidative stress basal ganglia neural regeneration 
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