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AGONISTS: 作品数：139被引量：373H指数：10; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王昊刘洪瑞李智郭政东蒋华良更多>>; 相关机构：北京大学中国医科大学中国科学院北京中医药大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划SA-SIBS优秀人才奖励基金更多>>

Anemia risk and mitigation strategies in type 2 diabetic patients:The role of novel antidiabetic agents: 《World Journal of Diabetes》2025年第5期119-123,共5页Petra Meliš Maja Cigrovski Berkovic; Anemia is a common yet often overlooked complication in patients with type 2 diabetes mellitus(T2DM),particularly those with chronic kidney disease.It significantly impacts patients'quality of life,cardiovascular heal...; 关键词：ANEMIA Type 2 diabetes mellitus chronic kidney disease Iron deficiency METFORMIN Sodium-glucose cotransporter-2 inhibitors Glucagon-like peptide-1 receptor agonist Glucagon-like peptide-1 receptor agonist/GIP dual agonists

Getting the SCOOP on peptide ligands that regulate leaf senescence: 《Molecular Plant》2025年第3期384-385,共2页Judy A.Brusslan; GLP-1 agonists are popular weight loss and diabetes drugs.These drugs are peptide ligands that recognize the GLP-1 receptor,suppress appetite,and increase insulin sensitivity.Although not yet approved for human use,GL...; 关键词：Arabidopsis thaliana GLP receptor GLP antagonists GLP agonists peptide ligands arabidopsis thaliana leaf senescence

Tumor-responsive covalent organic polymeric nanoparticles enhancing STING activation for cancer immunotherapy: 《Chinese Chemical Letters》2025年第3期357-362,共6页Shuang Liang Jianjun Yao Dan Liu Mengli Zhou Yong Cui Zhaohui Wang; supported by the Beijing Natural Science Foundation(No.Z230021);the National Natural Science Foundation of China(No.52202356);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-RC350-001);the CAMS Innovation Fund for Medical Sciences(No.2022-I2M-1-013).; The cyclic guanosine monophosphate-adenosine monophosphate synthase and the stimulator of interferon genes(cGAS-STING)has emerged as a promising target for cancer immunotherapy.However,the development of natural STING...; 关键词：IMMUNOTHERAPY Covalent organic polymers Delivery STING agonists NANOPARTICLE

Exploring the therapeutic potential of glucagon-like peptide 1agonists in metabolic disorders: 《World Journal of Gastroenterology》2025年第4期169-175,共7页Adrián Cortés-Martín Julio Plaza-Diaz; This article comments on the work by Soresi and Giannitrapani.The authors have stated that one of the most novel and promising treatments for metabolic dysfunction-associated steatotic liver disease(MASLD)is the use o...; 关键词：Glucagon-like peptide 1 agonists Liver diseases Metabolic dysfunctionassociated steatotic liver disease Metabolic health PHARMACOTHERAPY Diet Gut microbiome Physical exercise LIFESTYLE Non-alcoholic fatty liver disease

Glucagon-like peptide-1 agonists:Role of the gut in hypoglycemia unawareness,and the rationale in type 1 diabetes: 《World Journal of Diabetes》2024年第11期2167-2172,共6页Hyder O Mirghani; Type 1 diabetes is increasing and the majority of patients have poor glycemic control.Although advanced technology and nanoparticle use have greatly enhanced insulin delivery and glucose monitoring,weight gain and hyp...; 关键词：Glucagon-like peptide-1 receptor agonists Glucagon response Hypoglycemia unawareness GUT Type 1 diabetes

Discovery of biosynthetic enzymes forβ-D-manno-heptoses across kingdoms:novel agonists for ALPK1/NF-κB-dependent immune response: 《Signal Transduction and Targeted Therapy》2024年第11期4760-4762,共3页Gunter Maubach Michelle C.C.Lim Michael Naumann; supported in part by DFG grant NA292/17-1.; A recent study by Tang et al.1 in Science reveals the crosskingdom widespread occurrence of functional nucleotidediphosphate(NDP)-heptose biosynthetic enzymes(HBEs)that accounts for the synthesis of NDP-heptoses to ac...; 关键词：king response. RAISE

A new mechanism of thyroid hormone receptorβagonists ameliorating nonalcoholic steatohepatitis by inhibiting intestinal lipid absorption via remodeling bile acid profiles: 《Acta Pharmacologica Sinica》2024年第10期2134-2148,共15页Kai Sun Nan-lin Zhu Su-ling Huang Hui Qu Yi-pei Gu Li Qin Jia Liu Ying Leng; supported by Shanghai Municipal Science and Technology Major Project and the Foundation of Shanghai Science and Technology Committee(Grant No.21DZ2291100).; Excessive dietary calories lead to systemic metabolic disorders,disturb hepatic lipid metabolism,and aggravate nonalcoholic steatohepatitis(NASH).Bile acids(BAs)play key roles in regulating nutrition absorption and sy...; 关键词：nonalcoholic steatohepatitis THRβagonists resmetirom bile acids composition CYP8B1 intestinal lipid absorption

Dual peroxisome proliferator-activated receptorα/δagonists:Hope for the treatment of alcohol-associated liver disease?被引量：1: 《World Journal of Gastroenterology》2024年第37期4163-4167,共5页Xin-Yang Zhang Qin-Jun-Jie Chen Feng Zhu Min Li Dan Shang; Supported by National Natural Science Foundation of China,No.82172754 and No.81874208;Natural Science Foundation Project of Hubei Province,No.2021CFB562.; In this letter,we review the article“Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease”.We focus specifically on the detrimental effects of alcoho...; 关键词：Alcohol-associated liver disease FIBROSIS Antifibrotic effect Elafibranor Peroxisome proliferator-activated receptor

4-1BB transcriptomic expression patterns across malignancies:Implications for clinical trials of 4-1BB agonists: 《Cancer Communications》2024年第10期1168-1172,共5页Yuji Uehara Shumei Kato Daisuke Nishizaki Hirotaka Miyashita Suzanna Lee Mary K.Nesline Sarabjot Pabla Jeffrey M.Conroy Paul DePietro Heidi Ko Jason K.Sicklick Razelle Kurzrock; funded in part by the National Institutes of Health(grant numbers:5U01CA180888-08 and 5UG1CA233198-05.)。; 4-1BB,a member of the tumor necrosis factor receptor superfamily,is an important co-stimulatory molecule regulating the activity of immune cells across a range of physiological and pathological processes,which culmina...; 关键词：clinical utilizing FIGURE

Peroxisome proliferator-activated receptor agonists:A new hope towards the management of alcoholic liver disease: 《World Journal of Gastroenterology》2024年第35期3965-3971,共7页Siva Sundara Kumar Durairajan Abhay Kumar Singh Ashok Iyaswamy; In this editorial,we examine a paper by Koizumi et al,on the role of peroxisome proliferator-activated receptor(PPAR)agonists in alcoholic liver disease(ALD).The study determined whether elafibranor protected the inte...; 关键词：Alcoholic liver disease Peroxisome proliferator-activated receptors Peroxisome proliferator-activated receptors agonists Liver fibrosis INFLAMMATION Metabolic regulation HEPATOPROTECTION

AGONISTS