Peroxisome proliferator-activated receptor agonists:A new hope towards the management of alcoholic liver disease  

作　　者：Siva Sundara Kumar Durairajan Abhay Kumar Singh Ashok Iyaswamy 

机构地区：[1]Department of Microbiology,School of Life Sciences,Central University of Tamil Nadu,Tiruvarur 610005,India [2]School of Biomedical Sciences,Li Ka Shing Faculty of Medicine,University of Hong Kong,Hong Kong 999077,China [3]School of Chinese Medicine,Hong Kong Baptist University,Hong Kong 999077,China [4]Department of Biochemistry,Karpagam Academy of Higher Education,Coimbatore 641021,India

出　　处：《World Journal of Gastroenterology》2024年第35期3965-3971,共7页世界胃肠病学杂志（英文版）

摘　　要：In this editorial,we examine a paper by Koizumi et al,on the role of peroxisome proliferator-activated receptor(PPAR)agonists in alcoholic liver disease(ALD).The study determined whether elafibranor protected the intestinal barrier and reduced liver fibrosis in a mouse model of ALD.The study also underlines the role of PPARs in intestinal barrier function and lipid homeostasis,which are both affected by ALD.Effective therapies are necessary for ALD because it is a critical health issue that affects people worldwide.This editorial analyzes the possibility of PPAR agonists as treatments for ALD.As key factors of inflammation and metabolism,PPARs offer multiple methods for managing the complex etiology of ALD.We assess the abilities of PPARα,PPARγ,and PPARβ/δagonists to prevent steatosis,inflammation,and fibrosis due to liver diseases.Recent research carried out in preclinical and clinical settings has shown that PPAR agonists can reduce the severity of liver disease.This editorial discusses the data analyzed and the obstacles,advantages,and mechanisms of action of PPAR agonists for ALD.Further research is needed to understand the efficacy,safety,and mechanisms of PPAR agonists for treating ALD.

关 键 词：Alcoholic liver disease Peroxisome proliferator-activated receptors Peroxisome proliferator-activated receptors agonists Liver fibrosis INFLAMMATION Metabolic regulation HEPATOPROTECTION 

分 类 号：R575[医药卫生—消化系统]