UROGUANYLIN

作品数：3被引量：11H指数：2
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相关机构：中国科学院更多>>
相关期刊：《World Journal of Gastroenterology》《World Journal of Gastrointestinal Pharmacology and Therapeutics》更多>>
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Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models被引量：6
《World Journal of Gastroenterology》2018年第17期1888-1900,共13页Illona-Marie Boulete Anusha Thadi Catherine Beaufrand Viren Patwa Apoorva Joshi John A Foss E Priya Eddy Helene Eutamene Vaseem A Palejwala Vassilia Theodorou Kunwar Shailubhai 
Supported by Synergy Pharmaceuticals Inc.,which provided the funding and the plecanatide,dolcanatide and placebo used for these studies
AIM To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability, integrity of tight junctions and on suppression of visceral hypersensitivity. METHODS Transport of fluorescein...
关键词：Plecanatide Guanylyl cyclase-C AGONISTS Dolcanatide UROGUANYLIN PRECLINICAL cyclic GUANOSINE MONOPHOSPHATE Constipation Inflammatory bowel diseases 
Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice被引量：7
《World Journal of Gastrointestinal Pharmacology and Therapeutics》2017年第1期47-59,共13页Wen-Chi L Chang Shet Masih Anusha Thadi Viren Patwa Apoorva Joshi Harry S Cooper Vaseem A Palejwala Margie L Clapper Kunwar Shailubhai 
Supported by National Cancer Institute(CA133689 to Kunwar Shailubhai,CA006927 to Fox Chase Cancer Center);an appropriation from the Commonwealth of Pennsylvania(Fox Chase Cancer Center)
AIM To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc^(+/Min-FCCC) mice with dextran sodium sulfate(DSS)-induced inflammation. METHODS Inflammation driven colorectal carcinogenes...
关键词：Guanylate cyclase-C UROGUANYLIN Plecanatide INFLAMMATION Colorectal cancer 
Guanylyl cyclase C signaling axis and colon cancer prevention被引量：2
《World Journal of Gastroenterology》2016年第36期8070-8077,共8页Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman 
Supported by NIH,No.R01CA170533,No.R01CA206026 and No.P30CA56036;Targeted Diagnostic and Therapeutics,Inc.;a Ruth L.Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows from the NIH,No.CA180500(To Blomain ES);a Ruth L.Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows from the NIH,No.F30 DK103492(To Merlino DJ);a Predoctoral Fellowship in Pharmacology/Toxicology from the PhR MA Foundation
Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, a...
关键词：Colorectal cancer GUANYLIN UROGUANYLIN Chemoprevention Heat-stable ENTEROTOXINS Cyclic GUANOSINE MONOPHOSPHATE Guanylyl CYCLASE C 
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