MONOPHOSPHATE

作品数：92被引量：261H指数：8
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相关机构：南京工业大学南京大学福建中医药大学中国人民解放军第一军医大学更多>>
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Chitosan alleviates symptoms of Parkinson's disease by reducing acetate levels, which decreases inflammation and promotes repair of the intestinal barrier and blood–brain barrier
《Neural Regeneration Research》2026年第1期377-391,共15页Yinying Wang Rongsha Chen Guolin Shi Xinwei Huang Ke Li Ruohua Wang Xia Cao Zhongshan Yang Ninghui Zhao Jinyuan Yan 
supported by the National Natural Science Foundation of China,Nos. 32260196 (to JY), 81860646 (to ZY) and 31860274 (to JY);a grant from Yunnan Department of Science and Technology,Nos. 202101AT070251 (to JY), 202201AS070084 (to ZY), 202301AY070001-239 (to JY), 202101AZ070001-012, and 2019FI016 (to ZY)。
Studies have shown that chitosan protects against neurodegenerative diseases. However, the precise mechanism remains poorly understood. In this study, we administered chitosan intragastrically to an MPTP-induced mouse...
关键词：ACETATE adenosine 5′-monophosphate-activated protein kinase blood–brain barrier CHITOSAN dopamine neurons INFLAMMATION intestinal barrier Parkinson's disease peroxisome proliferator-activated receptor delta short-chain fatty acids 
Bioinspired Surface Engineering with Dual Covalent Receptors Incorporated via Precise Post-Imprinting Modification to Enhance the Specific Identification of Adenosine 5′-Monophosphate
《Engineering》2025年第2期143-154,共12页Pan Wang Tao Cheng Zhuangxin Wei Lu Liu Yue Wang Xiaohua Tian Jianming Pan 
supported by the National Natural Science Foundation of China(22078132,22108103,and U22A20413);the Open Funding Project of the National Key Labora-tory of Biochemical Engineering(2021KF-02);China Postdoctoral Science Foundation(2021M691301);Jiangsu Key Research and Development Program(BE2022356);the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(CPSF)(GZ20230989);Jiangsu Agricultural Independent Innovation Fund Project(CX(21)3079).
Expanding the specific surface area of substrates and carrying out precise surface engineering of imprinted nanocavities are crucial methods for enhancing the identification efficiency of molecularly imprinted polymer...
关键词：Precise surface engineering Dual covalent receptor Precise post-imprinting modification Specific identification of adenosine 5-monophosphate 
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1a axis to alleviate ferroptosis in metabolic-associated fatty liver disease
《Acta Pharmaceutica Sinica B》2025年第1期151-167,共17页Aoxiang Zhuge Shengjie Li Shengyi Han Yin Yuan Jian Shen Wenrui Wu Kaicen Wang Jiafeng Xia Qiangqiang Wang Yifeng Gu Enguo Chen Lanjuan Li 
supported by the National Natural Science Foundation of China(81790631,81874142,and 82073041);the National Key Research and Development Program of China(2018YFC2000500,2021YFA1301104,and 2021YFC2301804);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-045,China);the Research Project of Jinan Microecological Biomedicine Shandong Laboratory(JNL-2022001A,China);the China Postdoctoral Science Foundation(2023M743125).
Emerging evidences have indicated the role of ferroptosis in the progression of metabolicassociated fatty liver disease(MAFLD);thus,inhibiting ferroptosis is a promising strategy for the development of MAFLD therapeut...
关键词：Metabolic-associated fatty liver disease Ferroptosis Lipid peroxidation Akkermansia muciniphila ACETATE Adenosine 50-monophosphate 
Fanlian Huazhuo Formula:A promising herbal preparation for metabolic liver disease被引量：1
《World Journal of Gastroenterology》2024年第46期4964-4968,共5页Bhupesh Singla 
Supported by the National Institutes of Health Grants,No.K99HL146954 and No.R00HL146954;the College of Pharmacy Seed Research Grant Program of the University of Tennessee Health Science Center.
The prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)has increased significantly in recent decades and is projected to increase further due to the rising obesity rates.MASLD patients are at...
关键词：Metabolic dysfunction-associated steatotic liver disease Fanlian Huazhuo Formula De novo lipogenesis Cell death Adenosine-5’-monophosphate-activated protein kinase alpha Acetyl-CoA carboxylase 
Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula:Evidence,mechanisms and perspective
《World Journal of Hepatology》2024年第10期1208-1212,共5页Nabil Eid Payal Bhatnagar Li-Li Chan Marina Garcia-Macia 
In this letter,we comment on a recent publication by Mei et al,in the World Journal of Hepatology,investigating the hepatoprotective effects of the modified Xiaoyao San(MXS)formula in a male rat model of non-alcoholic...
关键词：STEATOSIS Liver Xiaoyao San Inflammation ANDROGEN Adenosine 5’-monophosphate-activated protein kinase Phosphatase and tensin homolog Autophagy Lipophagy Alpha smooth muscle actin 
Clean-DM1, a Korean Polyherbal Formula, Improves High Fat Diet-Induced Diabetic Symptoms in Mice by Regulating IRS/PI3K/AKT and AMPK Expressionsin Pancreas and Liver Tissues
《Chinese Journal of Integrative Medicine》2024年第2期125-134,共10页Piao Wang Yi Liu Seok Yong Kang Chenzi Lyu Xiang Han Tianjun Ho Kyung Jae Lee Xianglong Meng Yong-Ki Park Hyo Won Jung 
Supported by Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI),the Ministry of Health&Welfare,Republic of Korea (No. HF20C0121);Shanxi Key Laboratory of Tradition Herbal Medicines Processing (No. 20210901);the Innovation Team of Shanxi University of Chinese Medicine (No. 2022TD1014)
Objective:To investigate the effects of Clean-DM1(C-DM1),a polyherbal formulation of Radix Scrophulariae,Radix Astragali,Rhizoma Atractylodis,and Radix Salviae Miltiorrhizae,on high-fat diet(HFD)-induced diabetes mice...
关键词：high-fat diet type 2 diabetes mellitus herbal formulation insulin receptor substrate/phosphatidylinositol 3 kinase/protein kinase B adenosine 5'-monophosphate-activated protein kinase network pharmacology high performance liquid chromatography-mass spectrometry analysis 
Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway被引量：1
《Neural Regeneration Research》2023年第9期2067-2074,共8页Tong-Tong Lin Chun-Yi Jiang Lei Sheng Li Wan Wen Fan Jin-Can Li Xiao-Di Sun Chen-Jie Xu Liang Hu Xue-Feng Wu Yuan Han Wen-Tao Liu Yin-Bing Pan 
supported by the National Natural Science Foundation of China;Nos.81971047 (to WTL) and 82073910 (to XFW);the Natural Science Foundation of Jiangsu Province,No.BK20191253 (to XFW);Key R&D Program (Social Development) Project of Jiangsu Province,No.BE2019 732 (to WTL);Jiangsu Province Hospital (the First Affiliated Hospital of Nanjing Medical University) Clinical Capacity Enhancement Project,No.JSPH-511B2018-8 (to YBP)。
Opioids,such as morphine,are the most potent drugs used to treat pain.Long-term use results in high tolerance to morphine.High mobility group box-1(HMGB1) has been shown to participate in neuropathic or inflammatory p...
关键词：adenosine 5’-monophosphate-activated protein kinase heme oxygenase-1 high mobility group box-1 INTERLEUKIN-1Β MICROGLIA morphine tolerance NEUROINFLAMMATION neuron nuclear factor-κB p65 Toll-like receptor 4 
Emodin Ameliorates High Glucose-Induced Podocyte Apoptosis via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway被引量：3
《Chinese Journal of Integrative Medicine》2023年第9期801-808,共8页LIU Hong CHEN Wei-dong HU Yang-lin YANG Wen-qiang HU Tao-tao WANG Huan-lan ZHANG Yan-min 
Supported by the Chinese Medicine Research Project of Hubei Provincial Health Commission(No.ZY2019Q024);Scientific Research Project of Wuhan Municipal Health Commission(No.WX20B11);Scientific Research Project of Wuhan Municipal Health Commission(No.WZ20C01)。
Objective To investigate the effect of emodin on high glucose(HG)-induced podocyte apoptosis and whether the potential anti-apoptotic mechanism of emodin is related to induction of adenosine-monophosphate-activated pr...
关键词：EMODIN diabetic nephropathy AUTOPHAGY podocyte apoptosis adenosine-monophosphate-activated protein kinase/mammalian target of rapamycin signaling pathways 
A live attenuated RHΔompdcΔuprt mutant of Toxoplasma gondii induces strong protective immunity against toxoplasmosis in mice and cats
《Infectious Diseases of Poverty》2023年第3期51-66,共16页Yu Shen Bin Zheng Hao Sun Songrui Wu Jiyuan Fan Jianzu Ding Meng Gao Qingming Kong Di Lou Haojie Ding Xunhui Zhuo Shaohong Lu 
supported by the National Natural Science Foundation of China(No.81871684,No.81802037);the Provincial Key R&D program of Zhejiang Department of Science and Technology(No.2019C03057);the Zhejiang Provincial Natural Science Foundation of China(No.LY22H190003);the Zhejiang Medical and Health Science and Technology Plan(WKJ-ZJ-2203);the Central Leading Local Science and Technology Development Fund Project(2023ZY1019);the Key Discipline of Zhejiang Province in Public Health and Preventive Medicine(First Class,Category A),Hangzhou Medical College.
Background Toxoplasma gondii is an obligate intracellular apicomplexan parasite and is responsible for zoonotic toxoplasmosis.It is essential to develop an effective anti-T.gondii vaccine for the control of toxoplasmo...
关键词：Toxoplasma gondii Orotidine-5’-monophosphate decarboxylase PHOSPHORIBOSYLTRANSFERASE Live attenuated vaccine IMMUNIZATION Mouse Cat 
Enhanced production of cytidine 5'-monophosphate using biocatalysis of di-enzymes immobilized on amino-functionalized sepharose
《Chinese Journal of Chemical Engineering》2023年第6期40-52,共13页Xiaohong Zhou Wenfeng Zhou Wei Zhuang Chenjie Zhu Hanjie Ying Hongman Zhang 
supported by grants from the National Key Research and Development Program of China(2021YFC2102805,2019YFD1101204);the National Natural Science Foundation of China(21878142,21776132);Key Research and Development Plan of Jiangsu Province(BE2020712);Key Research and Development Plan of Jiangsu Province(BE2019001);Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20190035);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
Cytidine 5'-monophosphate(5'-CMP)is an essential nucleotide for additives.In this study,enhanced production of 5'-CMP was realized by the transformation of cytidine using co-immobilized di-enzymes,uridine-cytidine kin...
关键词：SEPHAROSE Ε-POLYLYSINE Dual-enzyme cascade Cytidine 5'-monophosphate Enzyme immobilization 
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