PHOSPHORIBOSYLTRANSFERASE

作品数：7被引量：1H指数：1
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A live attenuated RHΔompdcΔuprt mutant of Toxoplasma gondii induces strong protective immunity against toxoplasmosis in mice and cats
《Infectious Diseases of Poverty》2023年第3期51-66,共16页Yu Shen Bin Zheng Hao Sun Songrui Wu Jiyuan Fan Jianzu Ding Meng Gao Qingming Kong Di Lou Haojie Ding Xunhui Zhuo Shaohong Lu 
supported by the National Natural Science Foundation of China(No.81871684,No.81802037);the Provincial Key R&D program of Zhejiang Department of Science and Technology(No.2019C03057);the Zhejiang Provincial Natural Science Foundation of China(No.LY22H190003);the Zhejiang Medical and Health Science and Technology Plan(WKJ-ZJ-2203);the Central Leading Local Science and Technology Development Fund Project(2023ZY1019);the Key Discipline of Zhejiang Province in Public Health and Preventive Medicine(First Class,Category A),Hangzhou Medical College.
Background Toxoplasma gondii is an obligate intracellular apicomplexan parasite and is responsible for zoonotic toxoplasmosis.It is essential to develop an effective anti-T.gondii vaccine for the control of toxoplasmo...
关键词：Toxoplasma gondii Orotidine-5’-monophosphate decarboxylase PHOSPHORIBOSYLTRANSFERASE Live attenuated vaccine IMMUNIZATION Mouse Cat 
Interference of Quinolinate Phosphoribosyltransferase Gene QPT Affects Agronomic Traits and Leaf Quality in Nicotiana tabacum L.
《Journal of Agricultural Science and Technology(B)》2020年第4期229-245,共17页Chun Wei Zhi-Hui Du Li-Jun Qin De-Gang Zhao 
This study was supported by the Major Special Projects for the Cultivation of New National Genetically Modified Varieties(Contract No.2016ZX08010013-002);the Guizhou Science and Technology Plan Project(Contract No.[2016]7449);the Talent Training Program of Guizhou University(Contract No.[2018]5781).
Quinolinate phosphoribosyltransferase(QPRTase),a key enzyme in ensuring nicotinic acid is available for the synthesis of defensive pyridine alkaloids in Nicotiana species,also plays an important role in nicotinamide a...
关键词：Nicotiana tabacum QPT gene physiological characteristics tobacco quality 
X-Ray Induced Mutation Frequency at the <i>Hypoxanthine Phosphoribosyltransferase</i>Locus in Clinically Relevant Radioresistant Cells
《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》2017年第4期377-391,共15页Yoshikazu Kuwahara Mehryar Habibi Roudkenar Yusuke Urushihara Yohei Saito Kazuo Tomita Amaneh Mohammadi Roushandeh Tomoaki Sato Akihiro Kurimasa Manabu Fukumoto 
To elucidate the molecular mechanisms underlying cellular radioresistance, clinically relevant radioresistant cell lines were established via long-term exposure to X-rays with stepwise dose escalation. Established cel...
关键词：Clinically RELEVANT Radioresistant (CRR) Cell Hypoxanthine PHOSPHORIBOSYLTRANSFERASE (HPRT) Mutation FREQUENCY Phosphorylated Histone H2AX (γH2AX) X-Rays 
A unique insertion of low complexity amino acid sequence underlies protein-protein interaction in human malaria parasite orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase被引量：1
《Asian Pacific Journal of Tropical Medicine》2014年第3期184-192,共9页Waranya Imprasittichai Sittiruk Roytrakul Sudaratana R.Krungkrai Jcrapan Krungkrai 
supported in part by Faculty of Graduate School(to W.L);Faculty of Medicine(contract no. RAH/54(1) to J.K.),Chulalongkorn University
Objective:To investigate the multienzyine complex formation of human malaria parasite Plasmodium falciparum[P.falciparum)orotate phosphoribosyltransferase(OPRT)and orotidine5'-monophosphate decarboxylase(OMPDC),the fi...
关键词：Malaria PLASMODIUM FALCIPARUM PYRIMIDINE biosynthesis Orotate PHOSPHORIBOSYLTRANSFERASE Orotidine 5’-monophosphate DECARBOXYLASE Multienzyme complex Proteomics 
Adenine phosphoribosyltransferase deficiency: Leave no stone unturned
《World Journal of Clinical Urology》2014年第3期218-226,共9页Guillaume Bollée Michel Daudon Irène Ceballos-Picot 
Adenine phosphoribosyltransferase(APRT)deficiency is a rare autosomal recessive disease leading to generation of large amounts of 2,8-dihydroxyadenine(DHA).DHA is excreted in urine,where it precipitates into crystals ...
关键词：ADENINE PHOSPHORIBOSYLTRANSFERASE Dihydroxyadenine UROLITHIASIS Crystalline NEPHROPATHY 2 8-dihydroxyadenine NEPHROPATHY 
OPRT Is a Potential Predictive Factor for the Response to S-1 in Gastric Cancer
《Journal of Cancer Therapy》2013年第1期104-111,共8页Tao Li Meiha Leong Jing Yuan Juan Li Lin Chen 
Objective: To analyze the impact of mRNA expression of oral fluoropyrimidine (S-1) metabolism (thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase [OPR...
关键词：S-1 CHEMOTHERAPY GASTRIC Cancer Orotate PHOSPHORIBOSYLTRANSFERASE BIOMARKER 
Structure-function Relationships in Human Hypoxanthine-guanine Phosphoribosyltransferase(HGPRT) by Random Mutagenesis
《Chemical Research in Chinese Universities》2006年第2期251-252,共2页Luke Guddat Anthony Farlow John de Jersey 
Hypoxanthine-guanine phosphoribosyltransferase （ HGPRT, EC 2.4.2.8） is a key enzyme of the purine salvage pathway, which allows recycling of purine bases into DNA and RNA. It is widely distributed in nature and has ...
关键词：Hypoxanthine-guanine phosphoribosyltransferase Random mutagenesis Structure-function relationship 
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