DECARBOXYLASE

作品数：58被引量：118H指数：5
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相关作者：颜宏利孙树汉章意亮王玉招更多>>
相关机构：第二军医大学更多>>
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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism
《Neural Regeneration Research》2025年第1期93-106,共14页Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo 
supported by the Research Project of the Shanghai Health Commission,No.2020YJZX0111(to CZ);the National Natural Science Foundation of China,Nos.82021002(to CZ),82272039(to CZ),82171252(to FL);a grant from the National Health Commission of People’s Republic of China(PRC),No.Pro20211231084249000238(to JW);Medical Innovation Research Project of Shanghai Science and Technology Commission,No.21Y11903300(to JG).
Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism....
关键词：aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease PARKINSONISM positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2 
Cucumber malate decarboxylase,CsNADP-ME2,functions in the balance of carbon and amino acid metabolism in fruit
《Horticulture Research》2023年第12期70-83,共14页Nan Shan Youjun Zhang Yicong Guo Wenna Zhang Jing Nie Alisdair R.Fernie Xiaolei Sui 
This work was supported by the National Natural Science Foundation of China(32272695 and 31972398 to X.S.);the National Key Research and Development Program of China(2019YFD1000300);the National Natural Science Foundation of China(31960591 to N.S.);the Max-Planck Society and European Union’s Horizon 2020 research and innovation programme,project PlantaSYST(SGA-CSA No.664621 and No.739582 under FPA No.664620);the China Agriculture Research System of MOF and MARA(CARS-23);the 111 Project of Ministry of Education of P.R.C.(B17043).
Central metabolism produces carbohydrates and amino acids that are tightly correlated to plant growth and thereby crop productivity.Malate is reported to link mitochondrial respiratory metabolism with cytosolic biosyn...
关键词：SUGAR CARBON thereby 
Identification of key residues for the activity of aspartate 4‑decarboxylase towards l‑3‑methylaspartate
《Systems Microbiology and Biomanufacturing》2023年第3期449-456,共8页Mingzhu Hao Laichuang Han Zhemin Zhou Zhongmei Liu 
the National Natural Science Foundation of China(21878125).
Aspartate 4-decarboxylase(ASD)has been modified to obtain the catalytic ability of the unnatural substrate l-3-methylaspartate.However,the mechanism remains to be clarified.In the present study,the semi-rational modif...
关键词：Aspartate 4-decarboxylase l-3-methylasparte Substrate-binging pocket Molecular dynamics simulation 
Renal tubule-targeted dexrazoxane suppresses ferroptosis in acute kidney injury by inhibiting ACMSD
《Nano Research》2023年第7期9701-9714,共14页Yunjing Zhang Jicheng Wu Quanlin An Huanhuan Zhu Xinwan Su Ying Wang Xishao Xie Jian Zhang Xi Yao Chunhua Weng Shi Feng Jianhua Mao Xianghui Fu Fei Han Xin Cao Ben Wang Weiqiang Lin 
This work was supported by grants from Zhejiang Provincial Natural Science Foundation of China(No.LZ22H050001);the National Natural Science Foundation of China(Nos.81970573,81670651,81900683,82000637,and 82173662);Zhejiang provincial program for the Cultivation of High-level Innovative Health talents,Natural Science Foundation of Shanghai(No.20ZR1410400);Medical Health Science and Technology Project of Zhejiang Provincial Health Commission(No.2020KY538).
Acute kidney injury(AKI)is a heterogeneous clinical complication with no existing definite or particular therapies.Therefore,molecular mechanisms and approaches for treating acute kidney injury are in urgent need.Here...
关键词：DEXRAZOXANE dexrazoxane-polysialic acid acute kidney injury ischemia-reperfusion injury ferroptosis α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase(ACMSD) 
A live attenuated RHΔompdcΔuprt mutant of Toxoplasma gondii induces strong protective immunity against toxoplasmosis in mice and cats
《Infectious Diseases of Poverty》2023年第3期51-66,共16页Yu Shen Bin Zheng Hao Sun Songrui Wu Jiyuan Fan Jianzu Ding Meng Gao Qingming Kong Di Lou Haojie Ding Xunhui Zhuo Shaohong Lu 
supported by the National Natural Science Foundation of China(No.81871684,No.81802037);the Provincial Key R&D program of Zhejiang Department of Science and Technology(No.2019C03057);the Zhejiang Provincial Natural Science Foundation of China(No.LY22H190003);the Zhejiang Medical and Health Science and Technology Plan(WKJ-ZJ-2203);the Central Leading Local Science and Technology Development Fund Project(2023ZY1019);the Key Discipline of Zhejiang Province in Public Health and Preventive Medicine(First Class,Category A),Hangzhou Medical College.
Background Toxoplasma gondii is an obligate intracellular apicomplexan parasite and is responsible for zoonotic toxoplasmosis.It is essential to develop an effective anti-T.gondii vaccine for the control of toxoplasmo...
关键词：Toxoplasma gondii Orotidine-5’-monophosphate decarboxylase PHOSPHORIBOSYLTRANSFERASE Live attenuated vaccine IMMUNIZATION Mouse Cat 
Using transcriptomics to reveal the molecular mechanism of higher alcohol metabolism in Saccharomyces cerevisiae被引量：2
《Food Bioscience》2023年第1期210-219,共10页Danyao Cui Ling Liu Xiaoyuan Zhang Liangcai Lin Xin Li Ting Cheng Chunhui Wei Yu Zhang Zheng Zhou Wei Li Cuiying Zhang 
Supported by Tianjin Science and Technology Project(22ZYJDSS00050);Project Program of Key Laboratory of Industrial Fermentation Microbiology,Ministry of Education,and Tianjin Key Laboratory of Industrial Microbiology,China(No.2020KF002);National Natural Science Foundation of China(31771969);Liquor Making Biological Technology and Application of key laboratory of Sichuan Province(NJ2020-02);Project Program of Tianjin Graduate Research and Innovation(No.2020YJSB124).
High alcohols are important flavor compounds in alcoholic beverages,but high concentration of high alcohols is harmful to human health.Higher alcohol synthesis pathways in brewing microorganisms have been investigated...
关键词：Saccharomyces cerevisiae Higher alcohol Transcriptomics sequencing Alcoholic beverage α-keto acid decarboxylase PDC1 gene 
The Effect of Methylation Modification of MDD on the Expression of Key Genes in the Process of Saponin Synthesis in Eleutherococcus senticosus
《Phyton-International Journal of Experimental Botany》2022年第12期2649-2668,共20页Minghui Cui Limei Lin Jie Zhang Xin Song Shuo Wang Jing Dong Xuelei Zhao Yuehong Long Zhaobin Xing 
funded by Natural Science Foundation of Hebei Province,Grant No.H2020209302 and Hebei Education Department Sponsored Scientific Research Projects,Grant No.ZD2019075.
Mevalonate pyrophosphate decarboxylase is a kind of key enzyme in the terpenoid synthesis pathway in Eleutherococcus senticosus.The results of bisulfite sequencing showed that there were three kinds of samples with a ...
关键词：Eleutherococcus senticosus mevalonate diphosphate decarboxylase DNA methylation transcription factors 
Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota被引量：31
《Acta Pharmaceutica Sinica B》2022年第8期3298-3312,共15页Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-Bo Zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li Yan Wang Jian-Dong Jiang Wu Zhong 
supported by Key Project of Beijing Natural Science Foundation (No.7181007,China);the CAMS Innovation Fund for Medical Sciences (CIFMS;Nos.2016-I2M-3-011,20211-I2M-007,2021-I2M-1-027,and 2021-I2M-1-028,China);National Natural Science Foundation of China (Nos.81973290 and 82173888);Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study (Z141102004414062,China)。
Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. H...
关键词：DEPRESSION Morinda oficinalis oligosaccharides Gut microbiota Tryptophan hydroxylase 5-Hydroxytryptophan decarboxylase 5-HYDROXYTRYPTOPHAN Serotonin Drug metabolism 
Cloning,purification,and characterization of branched-chain α-keto acid decarboxylases from Lactococcus lactis strains with different 3-methylbutanal production abilities被引量：2
《Food Bioscience》2022年第3期947-953,共7页Chen Chen Jiajie Yuan Haiyan Yu Xinman Lou Bei Wang Zhiyuan Xu Huaixiang Tian 
supported by the National Natural Science Foundation of China(No.31972197).
Lactococcus lactis is an important food-grade microorganism that has been successfully applied as a starter to increase the level of 3-methylbutanal produced during the ripening of cheese.Three variants of branched-ch...
关键词：Lactococcus lactis Branched-chainα-keto acid decarboxylase 3-Methylbutanal Thiamin diphosphate(ThDP)-dependent enzyme family 
Mitochondrial ACOD1/IRG1 in infection and sterile inflammation被引量：3
《Journal of Intensive Medicine》2022年第2期78-88,共11页Runliu Wu Rui Kang Daolin Tang 
Immunometabolism is a dynamic process involving the interplay of metabolism and immune response in health and diseases.Increasing evidence suggests that impaired immunometabolism contributes to infectious and inflamma...
关键词：Aconitate decarboxylase 1(ACOD1) SEPSIS INFLAMMATION METABOLISM Disease 
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