5-HYDROXYTRYPTOPHAN

作品数:8被引量:75H指数:4
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相关领域:医药卫生更多>>
相关作者:陈素清梁建辉李俊旭邓艳萍更多>>
相关机构:北京大学更多>>
相关期刊:《Journal of Ocean University of China》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chinese Medical Journal》更多>>
相关基金:国家自然科学基金北京市自然科学基金广东省自然科学基金国家高技术研究发展计划更多>>
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Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota被引量:30
《Acta Pharmaceutica Sinica B》2022年第8期3298-3312,共15页Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-Bo Zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li Yan Wang Jian-Dong Jiang Wu Zhong 
supported by Key Project of Beijing Natural Science Foundation (No.7181007,China);the CAMS Innovation Fund for Medical Sciences (CIFMS;Nos.2016-I2M-3-011,20211-I2M-007,2021-I2M-1-027,and 2021-I2M-1-028,China);National Natural Science Foundation of China (Nos.81973290 and 82173888);Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study (Z141102004414062,China)。
Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. H...
关键词:DEPRESSION Morinda oficinalis oligosaccharides Gut microbiota Tryptophan hydroxylase 5-Hydroxytryptophan decarboxylase 5-HYDROXYTRYPTOPHAN Serotonin Drug metabolism 
Evaluation of necrosis avidity of radioiodinated 5-hydroxytryptophan and its potential applications in myocardial infarction imaging
《Chinese Chemical Letters》2019年第1期83-86,共4页Lin Ma Lingqiao Cai Qiaomei Jin Jiajia Liang Dongjian Zhang Wei Liu Yicheng Ni Zhiqi Yin Jian Zhang Ke Pan 
partially supported by the National Natural Science Foundation of China (Nos. 81473120, 81501536, 81473120)
This study aimed to seek necrosis avid agents with high safety from DNA binding agents. The interaction of 5-hydroxytryptophan(5-HTP) with DNA was investigated by a series of spectroscopic studies. Then, 5-HTP was lab...
关键词:Radioiodinated 5-HYDROXYTRYPTOPHAN NECROSIS AVIDITY DNA GROOVE binding NECROTIC MYOCARDIUM imaging 
Two-step production of monoamines in monoenzymatic cells in the spinal cord:a different control strategy of neurotransmitter supply?
《Neural Regeneration Research》2016年第12期1904-1909,共6页Mengliang Zhang 
supported by the Crafoord Foundation;the Lundbeck Foundation;the Danish Medical Research Council
Monoamine neurotransmitters play an important role in the modulation of sensory, motor and autonomic functions in the spinal cord. Although traditionally it is believed that in mammalian spinal cord, monoamine neurotr...
关键词:non-monoaminergic cell monoamine precursor 5-hydroxytryptophan L-dopa serotonin dopamine tyrosine hydroxylase tryptophan hydroxylase aromatic L-amino acid decarboxylase spinal cord injury 
Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis被引量:24
《World Journal of Gastroenterology》2016年第12期3451-3459,共9页Feng-Yan Yu Shao-Gang Huang Hai-Yan Zhang Hua Ye Hong-Gang Chi Ying Zou Ru-Xi Lv Xue-Bao Zheng 
Supported by The Natural Science Foundation of Guangdong,No.S2012040006557
AIM: To study differences in the visceral sensitivity of the colonic mucosa between patients with diarrheapredominant irritable bowel syndrome(IBS-D) and those with ulcerative colitis(UC) in remission and to relate th...
关键词:Stomach type diarrhea Diarrhea-predominant irritable bowel syndrome Ulcerative colitis in remission 5-HYDROXYTRYPTOPHAN 
Analgesis and Wound Healing Effect of Chitosan and Carboxymethyl Chitosan on Scalded Rats被引量:5
《Journal of Ocean University of China》2014年第5期837-841,共5页HUANG Shuya HAN Baoqin SHAO Kai YU Miao LIU Wanshun 
supported by National High-Tech R&D Program of China (863 Program, 2014AA093605)
Analgesis and wound healing effect of chitosan and carboxymethyl chitosan on scalded rats were investigated. A II degree scald model was established in rats, which was subsequently treated with chitosan and carboxymet...
关键词:BRADYKININ 5-HYDROXYTRYPTOPHAN HYDROXYPROLINE carboxymethyl chitosan 
Effects of 5-hydroxytryptophan on morphine-induced sensitization in mice被引量:1
《Journal of Chinese Pharmaceutical Sciences》2008年第1期1-5,共5页李俊旭 陈素清 邓艳萍 梁建辉 
National Natural Science Foundation of China (Grant No. 30570653);National Basic Research Program of China (Grant No. 2003CB515400);985 Program of China Ministry of Education
To investigate the involvement of central serotonergic system in behavioral sensitization to morphine in mice. Male Kunming mice were treated (i.p.) with saline or morphine 10 mg/kg twice daily for 3 d and then drug...
关键词:5-HYDROXYTRYPTOPHAN MORPHINE Behavioral sensitization MICE 
Antidepressant-like effects of the ethanolic extract of XiaobuxinTang,a traditional Chinese herbal prescription in animal models of depression被引量:15
《Chinese Medical Journal》2007年第20期1792-1796,共5页ZHANG You-zhi LI Yun-feng YU Neng-jiang YUAN Li ZHAO Yi-min XIAO Wen-bin LUO Zhi-pu 
the National Natural Science Foundation of China(No.30400600)
Background Xiaobuxin-Tang, a traditional Chinese herbal prescription recorded in a silk scroll unearthed from Mogao Caves of Dunhuang has been indicated that it can remit depressive disorder. The present study was des...
关键词:Xiaobuxin-Tang traditional Chinese medicine ANTIDEPRESSANT forced swimming test tail suspension test 5-Hydroxytryptophan induced head-twitch response 
L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice
《Acta Pharmacologica Sinica》2004年第5期644-650,共7页Jian-huiLIANG Jun-xuLI Xu-huaWANG BiCHEN YingLU PanZHANG RongHAN Xiang-fengYE 
AIM: To investigate the involvement of L-type Ca2+ channels in antinociceptive action induced by the 5-HT precursor,5-hydroxytryptophan (5-HTP). METHODS: Female Kunming mice were treated with either 5-HTP (20-80 mg/k...
关键词:SEROTONIN 5-HYDROXYTRYPTOPHAN FLUOXETINE PARGYLINE calcium channel blockers pain measure-ment 
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