supported by Key Project of Beijing Natural Science Foundation (No.7181007,China);the CAMS Innovation Fund for Medical Sciences (CIFMS;Nos.2016-I2M-3-011,20211-I2M-007,2021-I2M-1-027,and 2021-I2M-1-028,China);National Natural Science Foundation of China (Nos.81973290 and 82173888);Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study (Z141102004414062,China)。
Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. H...
partially supported by the National Natural Science Foundation of China (Nos. 81473120, 81501536, 81473120)
This study aimed to seek necrosis avid agents with high safety from DNA binding agents. The interaction of 5-hydroxytryptophan(5-HTP) with DNA was investigated by a series of spectroscopic studies. Then, 5-HTP was lab...
supported by the Crafoord Foundation;the Lundbeck Foundation;the Danish Medical Research Council
Monoamine neurotransmitters play an important role in the modulation of sensory, motor and autonomic functions in the spinal cord. Although traditionally it is believed that in mammalian spinal cord, monoamine neurotr...
Supported by The Natural Science Foundation of Guangdong,No.S2012040006557
AIM: To study differences in the visceral sensitivity of the colonic mucosa between patients with diarrheapredominant irritable bowel syndrome(IBS-D) and those with ulcerative colitis(UC) in remission and to relate th...
supported by National High-Tech R&D Program of China (863 Program, 2014AA093605)
Analgesis and wound healing effect of chitosan and carboxymethyl chitosan on scalded rats were investigated. A II degree scald model was established in rats, which was subsequently treated with chitosan and carboxymet...
National Natural Science Foundation of China (Grant No. 30570653);National Basic Research Program of China (Grant No. 2003CB515400);985 Program of China Ministry of Education
To investigate the involvement of central serotonergic system in behavioral sensitization to morphine in mice. Male Kunming mice were treated (i.p.) with saline or morphine 10 mg/kg twice daily for 3 d and then drug...
the National Natural Science Foundation of China(No.30400600)
Background Xiaobuxin-Tang, a traditional Chinese herbal prescription recorded in a silk scroll unearthed from Mogao Caves of Dunhuang has been indicated that it can remit depressive disorder. The present study was des...
AIM: To investigate the involvement of L-type Ca2+ channels in antinociceptive action induced by the 5-HT precursor,5-hydroxytryptophan (5-HTP). METHODS: Female Kunming mice were treated with either 5-HTP (20-80 mg/k...