G-PROTEIN

作品数：57被引量：145H指数：7
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Sturge–Weber syndrome:an update for the pediatrician
《World Journal of Pediatrics》2024年第5期435-443,共9页Emilie Dingenen Damien Segers Hannelore De Maeseneer Dirk Van Gysel 
Sturge–Weber syndrome(SWS)is a rare congenital neurocutaneous disorder characterized by the simultaneous presence of both cutaneous and extracutaneous capillary malformations.SWS usually presents as a facial port-win...
关键词：Capillary malformations G-protein Gq-G11 Port-wine birthmark Neurocutaneous disorder Sturge-Weber syndrome 
Bile acids and coronavirus disease 2019
《Acta Pharmaceutica Sinica B》2024年第5期1939-1950,共12页Xiaoru Huang Xuening Liu Zijian Li 
This study was supported by National Natural Science Foundation of China(NSFC Grant Nos.U21A20336,81820108031,and 91939301);National Key Research and Development Program of China(Grant No.2022YFC3602400);Beijing Municipal Natural Science Foundation(Grant No.7222218,China);Medical research management/basic and clinical research unit of metabolic cardiovascular diseases,Chinese Academy of Medical Sciences(Grant No.2021RU003,China).
The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has been significantly alleviated.However,long-term health effects and prevention strategy remain un...
关键词：Bile acids COVID-19 Farnesoid X receptor G-protein-coupled bile acid receptor SARS-CoV-2 Angiotensin-converting enzyme 2 Ursodeoxycholic acid Chenodeoxycholic acid 
Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion
《World Journal of Gastrointestinal Surgery》2022年第12期1329-1339,共11页Ryo Yamamoto Sayuri Suzuki Koichiro Homma Shintaro Yamaguchi Tomohisa Sujino Junichi Sasaki 
BACKGROUND Patients with mesenteric ischemia frequently suffer from bowel necrosis even after revascularization.Hydrogen gas has showed promising effects for ischemiareperfusion injury by reducing reactive oxygen spec...
关键词：Hydrogen molecule Intestinal ischemia Ischemia-reperfusion injury Tissue protection Nonoperative management Leucine-rich repeat-containing G-protein-coupled 5 
The role of roof plate-specific spondins in liver homeostasis and disease
《Liver Research》2022年第3期139-145,共7页Le Yang Wenhui Yue Hang Zhang Yue Gao Lin Yang Liying Li 
This work was supported by grants from the Scientific Research Common Program of Beijing Municipal Commission of Education(No.KM202010025029);the National Natural Science Foundation of China(No.82070623 and 81970532);the Beijing Natural Science Foundation(No.7202007).
As evolutionarily conserved signals,roof plate-specific spondins(R-spondins;RSPOs)are a family with four members(RSPO1e4)exerting distinctly different functions.RSPOs have five receptors and correlate with different s...
关键词：Roof plate-specific spondin(RSPO) Leucine-rich repeat-containing G-proteincoupled receptor(LGR) Zinc and ring finger 3(ZNRF3) Ring finger protein 43(RNF43) WNT signaling pathway Liver homeostasis Liver fibrosis Liver cancer 
The G-protein α subunit GhGPA positively regulates Gossypium hirsutum resistance to Verticillium dahliae via induction of SA and JA signaling pathways and ROS accumulation被引量：4
《The Crop Journal》2021年第4期823-833,共11页Bin Chen Yan Zhang Jun Yang Man Zhang Qingming Ma Xingfen Wang Zhiying Ma 
supported by the National Key Research and Development Program of China(2016YFD0101006);the China Agricultural Research System(CARS15-03);the Outstanding Youth Found of Hebei Province(C2019204365)。
Verticillium wilt, a devastating disease in cotton caused by Verticillium dahliae, reduces cotton quality and yield. Heterotrimeric GTP-binding proteins, consisting of Ga, Gb, and Gc subunits, transducers of receptor ...
关键词：Gossypium hirsutum GhGPA Verticillium wilt Pathogenesis-related genes ROS 
Probiotics VSL#3 are effective in reversing non-alcoholic steatohepatitis in a mouse model被引量：11
《Hepatobiliary Surgery and Nutrition》2020年第2期170-182,共13页Prasant Kumar Jena Lili Sheng Yongchun Li Yui-Jui Yvonne Wan 
This study supported by grants funded by National Institutes of Health CA179582 and CA222490.
Background:Probiotic VSL#3 is used to treat ulcerative colitis.This study examines the effect of VSL#3 in non-alcoholic steatohepatitis(NASH)that has liver carcinogenic potential.Methods:Western diet(WD)-fed wild-type...
关键词：BILE acid(BA) farnesoid X receptor(FXR) G-PROTEIN coupled BILE ACID receptor-1(GPBAR1) microbiota inflammation. 
MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription被引量：6
《World Journal of Gastroenterology》2019年第45期6619-6633,共15页Liang Ge Yu Wang Quan-Hong Duan Song-Shan Liu Guo-Jing Liu 
BACKGROUND Gastric cancer(GC)has become a serious threat to people's health.Accumulative evidence reveals that dysregulation of numerous microRNAs(miRNAs)has been found during malignant formation.So far,the role of mi...
关键词：Gastric cancer G-protein-coupled receptor KINASE interacting protein-1 Invasion Migration MicroRNA-760 Proliferation 
The allosteric modulation effects of doxycycline, minocycline, and their derivatives on the neuropeptide receptor PAC1-R被引量：2
《Acta Biochimica et Biophysica Sinica》2019年第6期627-637,共11页Suqin Song Like Wang Junfeng Li Xiaoling Huang Rongjie Yu 
This work was supported by the grants from the National Natural Science Foundation of China (Nos.31100545 and 31670848);the Natural Science Foundation of Guangdong Province (No.2016A030313087).
Class B G-protein coupled receptors (GPCR) PAC1-R is a neuropeptide pituitary adenylate cyclase activating polypeptide(PACAP)-preferring receptor that mediates the effective neuroprotective activity.Based on our previ...
关键词：pituitary ADENYLATE cyclase-activating polypeptide G-PROTEIN coupled RECEPTOR PAC1-R allosteric modulator DOXYCYCLINE MINOCYCLINE N-terminal extra cellular domain 
Association of G-protein coupled purinergic receptor P2Y2 with ischemic stroke in a Han Chinese population of North China被引量：2
《Neural Regeneration Research》2019年第3期506-512,共7页Li-Ying Yuan Zhi-Yi He Lei Li Yan-Zhe Wang 
supported by the National Natural Science Foundation of China,No.81070913(to ZYH)
The G-protein-coupled purinergic receptor P2Y2(P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to ischemic stroke. This retrospective case-control study aimed to assess the relati...
关键词：nerve REGENERATION P2RY2 GENE ischemic stroke single nucleotide polymorphism CASE-CONTROL study haplotype northern Han Chinese POPULATION large-artery atherosclerosis small-artery occlusion hypertension candidate GENE neural REGENERATION 
Translational potential of allosteric modulators targeting the cannabinoid CB1 receptor被引量：1
《Acta Pharmacologica Sinica》2019年第3期324-335,共12页Dai Lu Sri Sujana Immadi Zhixing Wu Debra A.Kendall 
The cannabinoid type-1(CB1)receptor,a G-protein-coupled receptor,is an attractive target for drug discovery due to its involvement in many physiological processes.Historically,drug discovery efforts targeting the CB1 ...
关键词：ALLOSTERIC modulator CANNABINOID CB1 RECEPTOR G-protein-coupled RECEPTOR biased signaling functional selectivity therapeutic POTENTIAL drug discovery 
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