孕早期高蛋白膳食对子代大鼠CPT1的影响  

Effects of high protein diet during early pregnancy on CPT1 of offspring

作　　者：董艳梅[1,2] 李省三[1] 赵剑飞[1] 冯海英[1] 徐坤[3] 谢志平[1] 李继媛[1] 刘吉成[1] 

机构地区：[1]齐齐哈尔医学院,161006 [2]黑龙江中医药大学博士后流动站齐齐哈尔医药科学研究所工作站 [3]齐齐哈尔市第一医院

出　　处：《中国实用医药》2013年第36期29-30,共2页China Practical Medicine

基　　金：黑龙江省教育厅面上项目(项目编号:12531795)

摘　　要：目的探讨孕早期高蛋白质膳食(HPD)对子代肥胖和肉碱酰基转移酶1(CPT1)表达的影响,寻找肥胖防治的靶标和合理的孕期膳食。方法孕早期大鼠分别给予HPD和标准膳食(SD),其后代分别为高蛋白质组(HP)和对照组(CON),SD喂养至成年,高脂膳食诱导肥胖,FQ-PCR法检测CPT1mRNA的水平。结果与对照组相比,HPD大鼠子代的体重持续降低(P<0.05),CPT1 mRNA水平持续升高。结论孕早期HPD可通过程序性升高子代CPT1 mRNA的水平,降低肥胖的发生。Objective To study the effects of high protein diet（HPD） during early pregnancy on offspring carnitine acyltransferase 1 （CPT1） mRNA, and find out optimal pregnant diet. Methods Rats were fed with a HPD and standard diet （SD） during early pregnancy, respectively. Male offspring were high protein （HP） and control （CON） group, respectively. Offspring were fed with a SD until adult. Rats were fed with high fat diet to induce obesity. CPT1 gene was analyzed by FQ-PCR. Results Body weight were decreased and CPT1 mRNA were increased in HP group （P＆lt;0.05）. Conclusion HPD during early pregnancy can prevent offspring from obesity by mediating lipolysis.

关 键 词：肥胖 肉碱酰基转移酶1 膳食 CPT1 

分 类 号：R151[医药卫生—营养与食品卫生学]