GluN2A versus GluN2B:twins,but quite different  

作　　者：Xiao-Min Zhang Jian-Hong Luo 

机构地区：[1]Department of Neurobiology,Key Laboratory of Medical Neurobiology of the Ministry of Health of China,Zhejiang Province Key Laboratory of Neurobiology,Zhejiang University School of Medicine

出　　处：《Neuroscience Bulletin》2013年第6期761-772,共12页神经科学通报（英文版）

基　　金：supported by grants from the National Basic Research Development Program of China(2010CB912002);the National Natural Science Foundation of China(30730038 and 81171164)

摘　　要：N-Methyl-D-aspartate receptors（NMDARs） play vital roles in the central nervous system,as they are primary mediators of Ca2＋influx during synaptic activity.The subunits that compose NMDARs share similar topological structures but are distinct in distribution and pharmacological properties,as well as physiological and pathological functions,which make the NMDAR one of the most complex and elusive ionotropic glutamate receptors.In this review,we focus on GluN2A and GluN2B,the primary NMDAR subunits in the cortex and hippocampus,and discuss their differences in developmental expression,brain distribution,trafficking,and functional properties during neuronal activity.N-Methyl-D-aspartate receptors（NMDARs） play vital roles in the central nervous system,as they are primary mediators of Ca2＋influx during synaptic activity.The subunits that compose NMDARs share similar topological structures but are distinct in distribution and pharmacological properties,as well as physiological and pathological functions,which make the NMDAR one of the most complex and elusive ionotropic glutamate receptors.In this review,we focus on GluN2A and GluN2B,the primary NMDAR subunits in the cortex and hippocampus,and discuss their differences in developmental expression,brain distribution,trafficking,and functional properties during neuronal activity.

关 键 词：N-methyl-D-aspartate receptors GluN2A GluN2B developmental expression brain distribution FUNCTION TRAFFICKING 

分 类 号：R338[医药卫生—人体生理学]