肿瘤坏死因子α-308G/A基因多态性与胃癌预后的相关性  

Correlation between TNF-α-308 G/A polymorphism and prognosis of patients with gastric cancer

作　　者：史俊[1] 陆俊[1] 洪岩[1] 吴小红[1] 

机构地区：[1]宜兴市人民医院普通外科,江苏省214200

出　　处：《江苏医药》2014年第2期209-211,共3页Jiangsu Medical Journal

摘　　要：目的探讨肿瘤坏死因子α(TNF-α)-308G/A基因多态性对胃癌预后的影响。方法采用等位基因特异引物PCR法分别检测80例胃癌患者(胃癌组)和80例非癌症患者(对照组)的TNF-α-308G/A基因的基因型。结果胃癌组TNF-α-308位点G和A等位基因的分布频率分别为92.2%和7.8%,与对照组的94.6%和5.4%相仿(P>0.05)。TNF-α-308位点G和A等位基因的分布频率差异亦无统计学意义[OR=1.619,95%可信区间(CI):0.763-2.472,P>0.05]。TNF-α-308GA、AA基因型的胃癌患者存在组织分化差、临床分期晚的趋势。多因素Cox比例风险模型分析显示,GA、AA基因型胃癌患者的死亡风险为GG基因型的2.122倍(95%CI:1.451-3.692,P<0.01)。结论 TNF-α-308G/A基因多态性与胃癌易感性可能不相关;TNF-α-308GA和AA基因型是胃癌患者不良预后的危险因素。Objective To investigate the correlation between tumor necrosis factor-a（TNF-a）- 308 G/A polymorphism and prognosis of patients with gastric cancer. Methods The TNF-a-308 G/A genotypes of 80 patients with gastric cancer（group A） and 80 patients without cancer（group B） were detected using allele-specific polymerase chain reaction. Results The G and A allele frequencies in TNF-a-308 locus in group A were 92.2% and 7.8%, respectively,which were similar to 94. 6% and 5.4% in group B（P〈0. 05）. There was no significant difference in the frequencies between A allele carriers and G allele carriers（OR= 1. 619,95% CI：0. 763-2. 472,P〈0. 05）. The patients with TNF-a 308 GA or AA genotype showed the trends of poor tissue differentiation and advanced clinical stage in group A. Multivariate Cox proportional hazard model showed that the risk of death in patients with TNF-a-308 GA or AA genotype was 2. 122 times of that in patients with TNF-a-308 CG genotype （95 %CI： 1. 451-3. 692, P〈0. 01） in group A. Conclusion TNF-a-308 G/A polymorphism may not be correlated with the susceptibility to gastric cancer. TNF-a-308 GA and AA genotypes are the risk factors for poor prognosis in patients with gastric cancer.

关 键 词：胃癌 肿瘤坏死因子Α 基因多态性 TUMOR NECROSIS factor-α 

分 类 号：R735[医药卫生—肿瘤]