网络游戏成瘾者颞顶联合区功能连接的静息态fMRI研究  

Functional connectivity of temporal parietal junction in online game addicts：a resting-state functional magnetic resonance imaging study

作　　者：袁季 钱若兵 林彬 傅先明 魏祥品 翁传波 牛朝诗 汪业汉 

机构地区：[1]安徽医科大学附属省立医院神经外科脑功能与脑疾病安徽省重点实验室,合肥230001 [2]安徽医科大学第三附属医院合肥市滨湖医院神经外科

出　　处：《中华医学杂志》2014年第5期372-375,共4页National Medical Journal of China

基　　金：国家自然科学基金（30670683,30973084）;安徽省自然科学基金（070413264X,11040606M167）;安徽省卫生厅医学科研课题（09B137）

摘　　要：目的 利用静息态功能磁共振成像（fMRI）探讨颞顶联合区作为注意网络的组成部分在网络游戏成瘾发病机制中的作用.方法 网络游戏成瘾者以及健康志愿者各17例,利用网络成瘾诊断量表了解两组的网络成瘾自测（IAT）评分的差异,并通过神经心理学测评了解两组注意功能的差异;利用静息态fMRI扫描,数据采集后进行预处理,分别以左、右颞顶联合区为感兴趣脑区与全脑进行功能连接分析,比较两组之间颞顶联合区功能连接的变化情况.结果 网络游戏IAT评分成瘾组（71分±5分）明显高于健康对照组（19分±7分）,神经心理测评中出现明显的注意功能下降,差异有统计学意义（P＜0.05）;在静息状态下,与健康对照组比较,成瘾组右侧颞顶联合区与双侧腹内侧前额叶、海马及杏仁核功能连接减弱,而与右侧楔叶功能连接增强;左侧颞顶联合区与双侧额上回及额中回功能连接减弱,而与双侧楔叶功能连接增强（P＜0.05）.结论 网络游戏成瘾者颞顶联合区功能连接存在异常,颞顶联合区作为注意网络的重要组成部分参与了网络游戏成瘾的产生.Objective To explore the functions of temporal parietal junction （TPJ） as parts of attention networks in the pathogenesis of online game addiction using resting-state functional magnetic resonance imaging （fMRI）. Methods A total of 17 online game addicts （OGA） were recruited as OGA group and 17 healthy controls during the same period were recruited as CON group. The neuropsychological tests were perfotraed for all of them to compare the inter-group differences in the results of Internet Addiction Test （IAT） and attention functions. All fMRI data were preprocessed after resting-state fMRI scanning. Then left and right TPJ were selected as regions of interest （ROIs） to calculate the linear correlation between TPJ and entire brain to compare the inter-group differences. Results Obvious differences existed between OGA group （71 ± 5 scores ） and CON group （ 19 ± 7 scores ） in the IAT results and attention function （P 〈0. 05）. Compared with the controls, right TPJ in online game addicts showed decreased functional connectivity with bilateral ventromedial prefrontal cortex （VMPFC）, bilateral hippocampal gyrus and bilateral amygdaloid nucleus, but increased functional connectivity with right cuneus. However, left TPJ demonstrated decreased functional connectivity with bilateral superior frontal gyrus and bilateral middle frontal gyrus, but increased functional connectivity with bilateral cnneus （P 〈 0. 05）. Conclusion Altered functional connectivity of TPJ reflected its dysfunction in online game addicts. It suggests that TPJ is an important component of attention networks participating in the generation of online game addiction.

关 键 词：网络游戏成瘾 颞顶联合区 磁共振成像 功能连接 注意力 

分 类 号：R749.99[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]