重性抑郁症的静息态功能磁共振成像低频振幅研究  

Research on Amplitude of Low-frequency Fluctuation in Patients with Major Depression Based on Resting-state Functional Magnetic Resonance Imaging

作　　者：邱海棠[1] 刘海霞[1] 贺倩[2] 蒙华庆[1] 傅一笑[1] 杜莲[1] 邱田[1] 罗庆华[1] 

机构地区：[1]重庆医科大学附属第一医院心理卫生中心,重庆400016 [2]重庆医科大学附属第一医院放射科,重庆400016

出　　处：《生物医学工程学杂志》2014年第1期97-102,共6页Journal of Biomedical Engineering

摘　　要：应用功能磁共振成像(fMRI)低频振幅(ALFF)方法研究重性抑郁症(MDD)静息状态下脑活动。本研究利用GE公司生产的Signa3.0TMRI对MDD组(13人)和正常对照(HC)组(14人)均做静息态fMRI扫描。应用双样本t检验计算并对比两组ALFF改变的脑区。结果发现静息状态下,MDD组患者右内侧前额叶ALFF值较HC组增高,差异有统计学意义(P<0.001);MDD组患者左侧顶叶ALFF值较HC组减少,差异有统计学意义(P<0.001)。由此可以得知MDD患者静息态下右内侧前额叶及左侧顶叶脑功能区ALFF值产生显著变化。We investigated the baseline brain activity level in patients with major depressive disorder （MDD） by amplitude of low-frequency fluctuation （ALFF） based on resting state functional MRI （fMRI）. We examined 13 patients in the MDD group and 14 healthy volunteers in the control group by resting state fMRI on GE Signa 3.0T. We calculated and compared the ALFF values of the two groups. In the MDD group, ALFF values in the right medial prefrontal were higher than those in control group, with statistically significant differences （P〈0.001）. ALFF values in the left parietal in the MDD group were lower than those in control group with statistically significant differences （P〈0.001）. This resting-state fMRI study suggested that the alteration brain activity in the right medial prefrontal and left parietal ALFF contributed to the understanding of the pathophysiological mechanism of MDD patients.

关 键 词：重性抑郁症 静息态功能磁共振成像 低频振幅 

分 类 号：R749.4[医药卫生—神经病学与精神病学]