Hypericin: chemical synthesis and biosynthesis  

作　　者：HUANG Lin-Fang WANG Zeng-Hui CHEN Shi-Lin 

机构地区：[1]Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences & Peking Union Medical College

出　　处：《Chinese Journal of Natural Medicines》2014年第2期81-88,共8页中国天然药物（英文版）

基　　金：supported by the Key National Natural Science Foundation of China(No.81130069);Selected Program of Personnel Department for Oversea Scholars(2009-2011);the Chinese National S&T Special Project on Major New Drug Innovation(No.2011ZX09307-002-01);the Key Technologies of the Quality Standards and the Safety of Health Food,"863 Program"(No.2010AA023006)

摘　　要：Hypericin is one of the most important phenanthoperylene quinones extracted mainly from plants of the genus Hypericum belonging to the sections Euhypericum and Campylosporus of Keller's classification. Widespread attention to the antiviral and anti-tumor properties of hypericin has spurred investigations of the chemical synthesis and biosynthesis of this unique compound. However, the synthetic strategies are challenging for organic and biological chemists. In this review, specific significant advances in total synthesis, semi-synthesis, and biosynthesis in the past decades are summarized.Hypericin is one of the most important phenanthoperylene quinones extracted mainly from plants of the genus Hy- pericum belonging to the sections Euhypericum and Campylosporus of Keller＇s classification. Widespread attention to the antiviral and anti-tumor properties of hypericin has spurred investigations of the chemical synthesis and biosynthesis of this unique compound. However, the synthetic strategies are challenging for organic and biological chemists. In this review, specific significant advances in total synthesis, semi-synthesis, and biosynthesis in the past decades are summa- rized.

关 键 词：HYPERICIN Total synthesis SEMI-SYNTHESIS BIOSYNTHESIS 

分 类 号：R284.3[医药卫生—中药学] Q81[医药卫生—中医学]