SEMI-SYNTHESIS

作品数：15被引量：10H指数：2
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相关领域：化学工程更多>>
相关机构：中国海洋大学更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Science China Chemistry》《Chinese Journal of Structural Chemistry》《Green Synthesis and Catalysis》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划更多>>
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(+)/(-)-Gerbeloid A,a pair of unprecedented coumarin-based polycyclic meroterpenoid enantiomers from Gerbera piloselloides:Structural elucidation,semi-synthesis,and lipid-lowering activity
《Acta Pharmaceutica Sinica B》2024年第6期2657-2668,共12页Chenxu Zhao Jingrong Li Yue Hu Lingyu Li Meng Yu Yunfeng Huang Tao Zhang Hai Shang Zhongmei Zou 
support from the Natural Sciences Foundation of China(82374035);the CAMS Innovation Fund for Medical Sciences(CIFMS,2022-I2M-1-017,China).
A pair of coumarin-based polycyclic meroterpenoid enantiomers(+)/(-)-gerbeloid A[(+)-1a and(-)-1b]were isolated from the medicinal plant Gerbera piloselloides,which have a unique caged oxatricyclo[4.2.2.0^(3,8)]decene...
关键词：Gerbera piloselloides Natural products Coumarin meroterpenoid Structural elucidation Biomimetic synthesis Lipid-lowering activity 3T3-L1 adipocytes High-fat diet zebrafish model 
Insertion of unnatural metal ligand in the heme pocket of nitrophorin through protein semi-synthesis:Toward biomimicking binuclear active sites
《Chinese Chemical Letters》2023年第12期132-135,共4页Yonglu Chen Yi Zhou Chunmao He 
financial support from the National Natural Science Foundation of China(Nos.22077036 and 22277029)is greatly acknowledged.
Herein,we report a semi-synthetic strategy affording a nitrophorin 2(NP2)variant with a N,N'-bis(2-pyridylmethyl)amine(Dpa)ligand as sidechain selectively installed at position 27,which was assembled from a synthetic ...
关键词：Protein semi-synthesis Protein modification Nitrophorin2 Heteronuclear active site Native chemical ligation 
Semi-synthesis of biotin-bearing activity-based ubiquitin probes through sequential enzymatic ligation,N-S acyl transfer and aminolysis reaction
《Chinese Chemical Letters》2023年第6期362-365,共4页Yu Wang Qiong Xia Xiao Hua Yanyan Guo Jing Shi Yi-Ming Li 
supported by the National Key R&D Program of China(No.2017YFA0505400);the National Natural Science Foundation of China(Nos.21877024,21972214 and 22277020)。
Activity-based Ubiquitin probes(Ub-ABPs)carrying a reporter group have emerged as effective tools for the investigation of deubiquitinating enzymes(DUBs),such as studying the molecular mechanism of DUBs,profiling new ...
关键词：UBIQUITINATION Deubiquitinating enzyme Activity-based ubiquitin probes Biotin tag Protein semi-synthesis 
Targeted isolation of antitubercular cycloheptapeptides and an unusual pyrroloindoline-containing new analog,asperpyrroindotide A,using LC–MS/MS-based molecular networking被引量：2
《Marine Life Science & Technology》2023年第1期85-93,共9页Yi-Qian Han Qun Zhang Wei-Feng Xu Yang Hai Rong Chao Cui-Fang Wang Xue-Mei Hou Mei-Yan Wei Yu-Cheng Gu Chang-Yun Wang Chang-Lun Shao 
This work was supported by the Program of National Natural Science Foundation of China(Nos.41906090,81874300,42006092,U1706210,41776141 and 41322037);the Program of Natural Science Foundation of Shandong Province of China(Nos.JQ201510 and ZR2019BD047);Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,Hainan Normal University(RDZH2021003);the Taishan Scholars Program,China(No.tsqn20161010).
Further insights on the secondary metabolites of a soft coral-derived fungus Aspergillus versicolor under the guidance of MS/MS-based molecular networking led to the isolation of seven known cycloheptapeptides,namely,...
关键词：Marine natural product MS/MS-based molecular networking Cycloheptapeptides SEMI-SYNTHESIS Anti-tubercular activity 
An asymmetric catalytic multi-component reaction enabled the green synthesis of isoserine derivatives and semi-synthesis of paclitaxel
《Green Synthesis and Catalysis》2023年第1期58-63,共6页Taoda Shi Xinglin Li Yukai Li Xiang Fu Linna Wu Dengqing Wu Wenhao Hu 
Support for this research from the National Natural Science Foundation of China(Nos.92056201 and 82003592);Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery(No.2019B030301005);The Program for Guangdong Introducing Innovative and Entrepreneurial Teams(No.2016ZT06Y337)and Zhujiang Talent Program Postdoctoral Funding Project is greatly acknowledged。
Paclitaxel(Taxol^(@))as a cornerstone of chemotherapy remains in high demand.The semi-synthesis of paclitaxel via coupling of Taxus leaf-produced baccatin III and manually synthesized isoserine(C-13 side chain)is one ...
关键词：Asymmetric catalysis Multi-component reaction Green semi-synthesis PACLITAXEL 
Simultaneous capture of ISG15 conjugating and deconjugating enzymes using a semi-synthetic ISG15-Dha probe被引量：1
《Science China Chemistry》2023年第3期837-844,共8页Chuntong Li Tian Wang Lujun Liang Guochao Chu Jiachen Zhang Wei He Lei Liu Jinghong Li 
supported by the National Key Research&Development Program of China(2021YFA1200104,2022YFC3401500);the National Natural Science Foundation of China(21621003,22137005,21971133,22027807,22034004,92253302,22227810);the Tsinghua University Spring Breeze Fund(2020Z99CFY043,2021Z99CFZ002)。
ISG15 is a ubiquitin-like(Ubl) protein attached to substrate proteins by ISG15 conjugating enzymes whose dysregulation is implicated in a multitude of disease processes, but the probing of these enzymes remains to be ...
关键词：ISG15-Dha probe SEMI-SYNTHESIS activity based probe PROTEOMICS ISGylation 
Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis
《Natural Products and Bioprospecting》2022年第1期78-106,共29页Ding Lin Senze Jiang Ailian Zhang Tong Wu Yongchang Qian Qingsong Shao 
supported by National Training Program of Innovation and Entrepreneurship for Undergraduates (202101341012);Talent Startup Project of Zhejiang A&F University Scientific Research and Development Fund (2034020154).
Structural derivatization of natural products has been a continuing and irreplaceable source of novel drug leads.Natural phenols are a broad category of natural products with wide pharmacological activity and have off...
关键词：Natural phenols Structural derivatization Common fragments Total synthesis 
Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin Ⅲ to baccatin Ⅲ被引量：2
《Acta Pharmaceutica Sinica B》2021年第10期3322-3334,共13页Hao Wang Bo-Yong Zhang Ting Gong Tian-Jiao Chen Jing-Jing Chen Jin-Ling Yang Ping Zhu 
supported by the National Key Research and Development Program of China(grant Nos.2018YFA0901900 and 2020YFA0908003);the Drug Innovation Major Project(grant No.2018ZX09711001-006-001,China);the National Natural Science Foundation of China(grant No.81573325);the CAMS Innovation Fund for Medical Sciences(CIFMS,(grant No.2017-I2M-2-004,2019-I2M-1-005,China);PUMC Disciplinary Development of Synthetic Biology(201920100801,China)。
10-DeacetylbaccatinⅢ(10-DAB)C10 acetylation is an indispensable procedure for Taxol semi-synthesis,which often requires harsh conditions.10-DeacetylbaccatinⅢ-10-β-O-acetyltransferase(DBAT)catalyzes the acetylation ...
关键词：Microbial cell factory Biosynthetic pathway of acetyl-CoA Bioconversion of 10-deacetylbaccatinⅢto baccatinⅢ 10-DeacetylbaccatinⅢ-10-β-Oacetyltransferase Deacetylation of baccatinⅢ High-cell-density fermentation Taxol semi-synthesis 
Semi-synthesis of Ubiquitin-propargylamide for identifying deubiquitinase targeting inhibitors被引量：1
《Chinese Chemical Letters》2019年第3期743-746,共4页Xiaodan Tan Jingsi Bai Shan Ding Yujing Ren Danning Hong Ziqing Mei Yi-Ming Li 
supported by the National Natural Science Foundation of China(Nos. 91753205 and 21877024 to Y. Li and No. 31640016 to Z. Mei);the Fundamental Research Funds for the Central Universities (No. PA2017GDQT0021 to Y. Li);the funding of National Key R&D program of China(No. 2017YFD0500400 to Z. Mei);the Fundamental Research Funds for the Central Non-profit Scientific Institution (No. Y2016JC25 to Z. Mei);the Agricultural Science and Technology Innovation Program to Z.Mei
Ubiquitin-propargylamide(Ub-PA) is one of the most widely used activity-based probe to measure the activity of deubiquitinases(DUBs) and help validate DUBs targeting inhibitors. However, current synthetic route of Ub-...
关键词：Deubiquitinase Activity-based probe Ubiquitin-propargylamide Protein SEMI-SYNTHESIS INHIBITOR identification 
Synthesis of Ras proteins and their application in biofunctional studies被引量：1
《Chinese Chemical Letters》2018年第7期1043-1050,共8页Jun Hu Pengcheng Zhu Yanmei Li Yongxiang Chen 
the National Natural Science Foundation of China (Nos. 21672125, 91753122)
Approximately 30% of human cancers are associated with RAS mutation. Ras proteins on the plasma membrane regulate a plenty of important cellular processes. The post-translational modifications(PTMs)of Ras proteins lik...
关键词：RAS LIPOPEPTIDES SEMI-SYNTHESIS Multi-PTMs Biophysical function 
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