HYPERICIN

作品数：20被引量：36H指数：3
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相关作者：胡正海吕洪飞沈宗根李景原刘文哲更多>>
相关机构：西北大学国立中兴大学中国医学科学院北京协和医学院清华大学更多>>
相关期刊：《Science China(Life Sciences)》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划陕西省教育厅科研计划项目更多>>
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Hypericin enhances superlubricity of glycerol by acting as graphene precursor
《Friction》2025年第1期195-204,共10页Paul Marie Zubieta-Laborde Yun Long Thomas Lubrecht Graham L.W.Cross Frédéric Dubreuil Jean Michel Martin Maria Isabel De Barros Bouchet 
funding from the HORIZON-EIC-2021-PATHFINDEROPEN-0 N.101046693,SSLiP project,funded by the European Union.
Hypericin(C30H16O8)is a naturally occurring substance,an anthraquinone derived from St.John’s wort,possessing outstanding antiviral,antitumor,antibacterial,and antioxidant properties.Today,hypericin is primarily used...
关键词：SUPERLUBRICITY boundary lubrication green lubrication pharmacopeia-derived additives 
In vitro 3D malignant melanoma model for the evaluation of hypericin-loaded oil-in-water microemulsion in photodynamic therapy
《Bio-Design and Manufacturing》2022年第4期660-673,共14页Hui LMa Wanlu Li Mian Wang Laudemir C.Varanda Janice R.Perussi Y.Shrike Zhang Emanuel Carrilho 
supported in part by the FAPESPINCTBio (Process 2014/50867-3);FAPESP-CEPOF (2013/072761);support by the Brigham Research Institute;LCV thanks FAPESP for financial support (Process 2013/01284-2)。
Advances in biomimetic three-dimensional(3D) melanoma models have brought new prospects of drug screening and disease modeling, since their physiological relevancy for recapitulating in vivo tumor architectures is mor...
关键词：Malignant melanoma 3D cell culture HYPERICIN MICROEMULSION Photodynamic therapy 
Biosynthesis of titanium dioxide nanoparticles using Hypericum perforatum and Origanum vulgare extracts and their main components,hypericin and carvacrol as promising antibacterial agents
《Journal of Traditional Chinese Medicine》2022年第2期167-175,共9页Mojtaba Khaksarian Mahmoud Bahmani Morovat Taherikalani Behnam Ashrafi Mahmoud Rafieian-Kopaei Naser Abbasi 
financial support of the Research and Technology Deputy of Lorestan University of Medical Sciences,Khorramabad,Iran。
OBJECTIVE:To evaluate the anti-bacterial activities of titanium dioxide(Ti O;)nanoparticles of Origanum(O.)vulgare and Hypericum(H.)perforatum extracts,carvacrol and hypericin against Staphylococcus(S.)aureus.METHODS:...
关键词：plant MEDICINAL MEDICINE TRADITIONAL anti-infective agents active ingredient nano-compounds 
Effect of Photoactivated Hypericin on Growth and Antibiotic Susceptibility of Hospital-Related Staphylococcus aureus and Enterococcus sp. Clinical Strains
《Advances in Biological Chemistry》2022年第4期116-129,共14页Maria Nagyova Leonard Siegfried Daniel Jancura Daniel Jancura Zuzana Nadova 
Resistance against commonly used antibiotics is a serious clinical problem in recent medical practice. There exist several bacterial strains in which the possibilities of their inhibition are very limited due to multi...
关键词：Antimicrobial Photodynamic Therapy HYPERICIN Antibiotic Resistance Methicillin-Resistant Staphylococcus aureus Vancomycin-Resistant Enterococcus sp. 
Effects of Different Geographical Aspects and Ontogenetic Variability on Total Hypericin Content of Hypericum triquetrifolium Turra. and Hypericum scabrum L.
《Phyton-International Journal of Experimental Botany》2020年第4期1091-1099,共9页Emine Aslan Dogan Arslan 
This publication was supported by Award Number(2016-SİUFEB-23)from the Research Foundation of Siirt University,Turkey.
The present study was conducted to determine the total hypericin contents of Hypericum triquetrifolium Turra.and Hypericum scabrum L.species which are naturally distributed in the flora of Siirt province,Turkey.Hyperi...
关键词：Hypericum triquetrifolium Hypericum scabrum ASPECT HYPERICIN 
Hypericin enhances β-lactam antibiotics activity by inhibiting sarA expression in methicillinresistant Staphylococcus aureus被引量：11
《Acta Pharmaceutica Sinica B》2019年第6期1174-1182,共9页Genzhu Wang Liang Li Xiukun Wang Xue Li Youwen Zhang Jie Yu Jiandong Jiang Xuefu You Yan Q.Xiong 
supported in part by CAMS Initiative for Innovative Medicine(grant numbers 2016-I2M-2-002 and 2016-I2M3-014,China);National Mega-project for Innovative Drugs(grant number 2018ZX09721001,China);the National Science Foundation of China(grant number 81621064,China).
Bacteremia is a life-threating syndrome often caused by methicillin-resistant Staphylococcus aureus(MRSA).Thus,there is an urgent need to develop novel approaches to successfully treat this infection.Staphylococcal ac...
关键词：Hyperiein Β-LACTAMS MRSA SYNERGISTIC effect SARA 
Topically applied hypericin exhibits skin penetrability on nude mice
《中国药理学与毒理学杂志》2017年第10期1020-1020,共1页Zhuo-heng LI Yuan-yuan LI Lai-chun LU Xiao-yu XU 
OBJECTIVE Hypericin,a powerful naturally photosensitizer in photodynamic therapy(PDT),is suitable for treating skin diseases involving excess capillary proliferation.In the present study,we aimed to evaluate the skin ...
关键词：HYPERICIN PHOTOSENSITIZER skin penetrability photodynamic therapy 
Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent
《World Journal of Gastroenterology》2016年第29期6690-6705,共16页Marlein Miranda Cona Ye-Wei Liu Antoine Hubert Ting Yin Yuan-Bo Feng Peter de Witte Etienne Waelkens Yan-Sheng Jiang Jian Zhang Stefaan Mulier Qian Xia Gang Huang Raymond Oyen Yi-Cheng Ni 
Supported by Research Foundation-Flanders(FWO);the KU Leuven Molecular Small Animal Imaging Center Mo SAIC,No.KUL EF/05/08;the center of excellence in vivo molecular imaging research(IMIR);KU Leuven projects,No.IOFHB/08/009 and No.IOF-HB/12/018;the European Union,AsiaLink Cf P 2006-Europe Aid/123738/C/ACT/Multi-Proposal,No128-498/111;National Natural Science Foundation of China,No.81071828;Jiangsu Province Natural Science Foundation,No.BK2010594
AIM: To explore the feasibility of using hypericin as an optical imaging probe with affinity for cholesterol for differential fluorescent detection of human gallstones.METHODS: Cholesterol, mixed and pigment stones fr...
关键词：Differential detection FLUORESCENCE Human GALLSTONES HYPERICIN Rat model of CHOLELITHIASIS 
Evaluation of photodynamic efficiency of an endogenous enzyme-NQO1 activated hypericin
《中国药理学与毒理学杂志》2015年第S1期94-94,共1页Qi-caiXIAO Wing-nangLEUNG Chuan-shanXU 
The project supported by the general grant fund from Hong Kong Research Grant Committee(476912);Health and Medical Research Fund(13120442);Innovation and Technology Fund of Shenzhen(CXZZ20120619150627260)
OBJECTIVE To investigate the therapeutic efficiency of an endogenous enzyme-NQO1 activated hypericin in photodynamic therapy.METHODS An endogenous enzyme-NQO1 responsive photo sensitizer was designed and synthesized b...
关键词：photodynamic THERAPY PHOTOSENSITIZER hypericin ROS 
Hypericin: chemical synthesis and biosynthesis被引量：1
《Chinese Journal of Natural Medicines》2014年第2期81-88,共8页HUANG Lin-Fang WANG Zeng-Hui CHEN Shi-Lin 
supported by the Key National Natural Science Foundation of China(No.81130069);Selected Program of Personnel Department for Oversea Scholars(2009-2011);the Chinese National S&T Special Project on Major New Drug Innovation(No.2011ZX09307-002-01);the Key Technologies of the Quality Standards and the Safety of Health Food,"863 Program"(No.2010AA023006)
Hypericin is one of the most important phenanthoperylene quinones extracted mainly from plants of the genus Hypericum belonging to the sections Euhypericum and Campylosporus of Keller's classification. Widespread atte...
关键词：HYPERICIN Total synthesis SEMI-SYNTHESIS BIOSYNTHESIS 
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