Xanthone对小鼠反复脑缺血再灌流后行为学的影响  

Effects of xanthone on mouse behaviors under repeated cerebral ischemia reperfusion condition

作　　者：何泉华[1] 邓芹英[2] 

机构地区：[1]广州医学院蛇毒所,广州510182 [2]中山大学化学与化学工程学院,广州510275

出　　处：《广东药学》2001年第1期3-4,共2页Guangdong Pharmaceutical Journal

摘　　要：观察Xanthone (XT)对小鼠反复脑缺血再灌流后行为学的影响。将 40只小鼠分为 4组 ,经反复脑缺血再灌流加降血压法造模后 ,分别给予注射用水、XT静脉注射高剂量 5 0mg/kg和低剂量 10mg/kg ,术后进行跳台、水迷宫实验测试。结果显示 ,模型组小鼠潜伏期缩短 ,游全程时间延长、错误次数增多 ;XT高、低二个剂量组均使上述指标改善 ,有显著性差异。揭示XT可对抗反复脑缺血再灌流后行为学的障碍 。mice models with vascular dementia(VD)were devided into 4 groups and administered respectively with injecting water,XT(10mg/kg,50mg/kg,iv).Observe their behaviors in step-down avoidance test and water-maze test.Results:The mouse's performance in the water labyrinth was obviously affected.The whole distance swimming time was prolonged and mistakes increased.XT can improve the above incidence and there was remarkable difference in statistics.It proved that XT could strengthen the mouse in earning and memory.

关 键 词：XANTHONE 脑缺血 学习 记忆 再灌注损伤 小鼠 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学] R338.64[医药卫生—临床医学]