Alzheimer病和血管性痴呆事件相关电位的对照研究  

A comparison study of event related potentials in Alzheimer disease and vascular dementia

作　　者：王晓红[1] 解恒革[1] 刘凤荣[1] 王鲁宁[1] 

机构地区：[1]解放军总医院,北京100853

出　　处：《现代康复》2001年第2期47-48,共2页Modern Rehabilitation

基　　金：军队"九五"课题! (98M139);国家卫生部"九五"攻关课题!(96- 906- 05- 07)

摘　　要：目的 探讨事件相关电位 P300在 Alzheimer病 (AD)和血管性痴呆 (VD)鉴别诊断中的作用。方法 对年龄匹配的 AD患者 30例， VD患者 16例，正常老年人对照组 41例进行 P300检查。结果 与正常老年人比较， AD和 VD患者 N1、 N2、 P3潜伏期均明显延长， AD和 VD组比较， AD患者 P3潜伏期显著延长，而 P3波幅显著降低。判别分析表明， P3潜伏期鉴别 AD的敏感性为 70％，特异性为 75％，总准确率为 72.5％ (P=0.002)。结论 由于病理基础不同， AD和 VD患者 P300也存在差异，此差异在痴呆的辅助鉴别诊断中有一定意义。Objective To investigate the effect of event related potentials in the differential diagnosis between Alzheimer disease and vascular dementia.Methods Event related potentials were performed in 30 patients with AD,16 with VD and 41 normal controls. Results The latencies of N1,N2,P3 were significantly prolonged in AD and VD group,when compared with normal controls.AD patients had a significant longer P3 latency and lower P3 amplitude than VD patients.The sensitivity and specificity of P3 latency in discriminant function analysis between AD and VD were 70％ and 75％ ,respectively.Conclusion The difference of P300 between AD and VD,which was related with their neuropathological basis,may be used if necessary.

关 键 词：阿尔茨海默病 血管性痴呆 事件相关电位 鉴别诊断 比较 AD 

分 类 号：R749.160.4[医药卫生—神经病学与精神病学] R749.130.4[医药卫生—临床医学]