黄芪渣虫草发酵产物的毒性实验研究  

Study on Toxicity Test of the Fermentation Product of Cordyceps with Astragalus Residues

作　　者：朱振元[1] 代丽翠 刘晓翠[1] 张静怡 孙会轻[1] 肖超岭 

机构地区：[1]食品营养与安全教育部重点实验室天津科技大学食品工程与生物技术学院,天津300347

出　　处：《食品研究与开发》2014年第2期95-98,共4页Food Research and Development

基　　金：国家农业科技成果转化资金项目(2011GB2A100009);国家星火计划项目(2012GA610005);天津市高等学校科技发展基金计划项目(20090604)

摘　　要：研究黄芪渣虫草发酵产物作为动物营养增强剂的毒理安全性。利用小鼠急性毒性试验、小鼠亚急性毒性试验进行毒理学研究。急性毒性试验表明黄芪渣虫草发酵产物对雌雄小鼠的最大耐受量(MTD)均大于35 000 mg/kg·bw,相当于奶牛的600倍、肉牛的12 000倍。根据急性毒性试验标准,说明受试物属于实际无毒级物质。亚急性毒性试验表明,15 000、10 000、5 000 mg/kg·bw剂量时,对动物身体、内脏的生长发育、血液生化指标、血常规等均无明显不良影响。黄芪渣虫草发酵产物为无毒产品,可放心作为动物营养增强剂及饲料添加剂使用。To study the toxicity of the fermentation product of Cordyceps with astragalus residues as animal nutrition enhancer. The acute toxicity test and sub-acute oral toxicity test for toxicological studies were conducted in mice. Acute toxicity test showed that the maximum tolerated dose （MTD）of the fermentation product of Cordyceps with astragalus residues to male and female mice were greater than 35 000 mg/kg bw, equivalent to 600 times as cows, 12 000 times as beef cattle. According to the acute toxicity test standards ,test substance is nontoxic substances. Sub-acute toxicity test shows that there was no significant adverse effects on the animal body, the growth and development of the internal organs, blood biochemical parameters, blood, etc. , by 15 000 mg/kg, bw, 10 000 mg/kg bw and 5 000 mg/kg bw dose. the fermentation product of Cordyceps with astragalus residues is nontoxic products that can be asured used as animal nutrition enhancers and feed additives.

关 键 词：黄芪渣 发酵产物 安全性 毒理试验 

分 类 号：TQ920.1[轻工技术与工程—发酵工程]