MED12基因突变与子宫平滑肌瘤发病关系的荟萃分析  

Relationship between MED12 mutation and development of uterine leiomyomas： a meta-analysis

作　　者：叶军[1] 陈亚宝[1] 沙敏[1] 马莹[1] 袁冬兰[1] 王华[1] 

机构地区：[1]江苏省泰州市人民医院临床医学研究所,225300

出　　处：《中华生物医学工程杂志》2013年第5期407-411,共5页Chinese Journal of Biomedical Engineering

摘　　要：目的 探讨MED12基因突变与子宫平滑肌瘤发病的关系.方法 检索1995年7月-2013年1月Medline、EMBASE、Ovid、Springer数据库、Cochrane图书馆收录的英文文献,以及1994年1月-2013年1月中国知网全文数据库（CNKI）和1978年1月-2013年1月中国生物医学文献数据库（CBMdisc）收录的中文文献.选择研究子宫肌瘤MED12基因突变情况的文献,探讨MED12基因突变与子宫平滑肌瘤发病的关系,分析不同人种子宫肌瘤MED12突变的情况和MED12突变类型在不同地区的分布.结果 纳入研究9篇文献合并分析共计641例患者,MED12基因突变率为64.90％（416/641）,非子宫平滑肌瘤的对照组为0.79％（17/2146）,差异有统计学意义（x2=1 540.848,P＜0.001）.MED12突变是子宫肌瘤发病的危险因素（OR=61.83,95％CI：33.82～ 113.03）.不同人种合并分析显示,白人的MED12基因突变率为68.99％（238/345）,黑人为62.75％（32/51）,黄种人为63.39％（71/112）,不同人种间的突变率比较差异无统计学意义（均P＞0.05）.不同地区人群子宫肌瘤MED12基因突变率合并分析显示,亚洲人群突变率为63.39％（71/112）,欧洲人群突变率为65.29％（222/340）,美洲人群突变率为67.70％（109/161）,非洲人群突变率为50.00％ （14/28）,非洲人群的突变率低于欧洲、美洲人群（均P＜0.05）.结论 MED12基因突变与子宫平滑肌瘤发病危险有关,突变情况与种族无关,部分地区MED12基因突变率存在差异.Objective To investigate the relationship between MED12 mutation and development of uterine leiomyoma.Methods A thorough search was performed of English language medical literatures published in Pubmed/Medline,EMBASE,Ovid,Springer and Cochrane from July 1995 through January 2013,and of Chinese language medical literatures in CNKI from January 1994 to January 2013,and CBMdisc from January 1978 to January 2013.Articles concerning MED12 mutations in uterine leiomyomas were retrieved for subsequent study on the relationship between MED 12 mutation and development of uterine leiomyoma,as well as the racial difference and geographical distribution of MED12 mutation.Results A total of 614 patients from 9 articles were enrolled in this study.The rate of MED12 mutation was 64.90％ （416/641）,which was statistically different from that （0.79％,17/2146） in the control group （x2=1 540.848,P＜0.001）.MED12 mutation was the risk factor for the development of uterine leiomyomas （OR=61.83,95％ CI：33.82-113.03）.Pooled analysis of ethnicity showed that the rate of MED12 mutation was 68.99％ （238/345） in Caucasians,62.75％ （32/51） in blacks,and 63.39％ （71/112） in Asians.Moreover,there was no significant difference in MED 12 mutation rate between ethnicity （all P＞O.05）.Pooled analysis of different regions showed that the rate of MED12 mutation was 63.39％ （71/112） in Asians,65.29％ （222/340） in Europeans,67.70％ （109/161） in America,50.00％ （14/28） in Africans.Africans had the lowest rate of MED12 mutation as compared with Europeans and Americans （both P＜0.05）.Conclusions MED12 mutation is correlated with the risk of uterine leiomyomas.Mutation of MED12 does not correlate with ethnicity,but may correlate with regional difference.

关 键 词：肌瘤 子宫 RNA聚合酶Ⅱ转录调节物12 突变 META分析 

分 类 号：R737.33[医药卫生—肿瘤]