电感耦合等离子体质谱技术测定痕量碘方法研究  

Research on trace iodine determination by inductively coupled plasma mass spectrometry

作　　者：张慧敏[1] 黎雪慧[1] 刘桂华[1] 黄铁军[1] 

机构地区：[1]深圳市疾病预防控制中心,广东深圳518055

出　　处：《中国卫生检验杂志》2014年第4期493-495,共3页Chinese Journal of Health Laboratory Technology

基　　金：深圳市科技研发资金基础研究计划项目(JC201105170709A)

摘　　要：目的建立水、尿及食品中痕量碘的电感耦合等离子体质谱检测方法,为碘营养状况的研究提供科学的检测技术。方法样品经质量分数为0.25%的四甲基氢氧化铵碱溶液稀释法或密闭溶样法处理后,应用电感耦合等离子体技术测定。结果方法的线性相关系数大于0.999 7;水样直接测定,检出限为0.20!g/L;尿液稀释10倍测定,方法检出限为0.13!g/L;食品以称取0.5 g定容至25 ml计,检出限为5.6!g/kg;分别对冻干人尿中碘、水中碘及食品中多种生物成分标准物质碘水平独立测试7次,其测定值的相对标准偏差均小于5%,且测定值均在标准值范围内。结论建立的分析方法操作简单、抗干扰性强、灵敏度高,适用于水、尿样、食品等大批量样品中痕量碘的快速准确测定。Objective To develop a method for the determination of iodine in water, urine and foodstuff samples by inductively coupled plasma mass spectrometry, so as to provide scientific detection technology for studying iodine nutrition status. Methods Samples were treated by 0.25% tetramethylammonium hydroxide solution dilution method or sealed digestion method, and then determined by inductively coupled plasma mass spectrometry. Results The correlation coefficients （R2） were above 0.9997. The limit of detection （LOD） was 0.20μg/L in water sample direct determination, and 0. 13μg/L in 10 -fold -dilution urine sample. The limit of detection （LOD） in foodstuff samples was 5.60μg/kg. For the determination of standard materials, the relative standard deviations were less than 5%. Conclusion The proposed method had advantages of easy operation, strong immunity from interference and high sensitivity, it is suitable for the determination of iodine in water, urine and foodstuff sam- pies in large quantity.

关 键 词：碘 电感耦合等离子体 饮用水 食品 尿 

分 类 号：R122.1[医药卫生—环境卫生学]