Tissue elasticity displayed by elastography and its correlation with the characteristics of collagen type I and type III in prostatic stroma  

【原创论文】前列腺组织弹性成像与间质中I、III型胶原纤维的关系

作　　者：Jie Tang Yan Zhang Ming-Bo Zhang Yan-Mi Li Xiang Fei Zhi-Gang Song 

机构地区：[1]Department of Ultrasound [2]Department of Pathology, Chinese People's Liberation Army General Hospital, Beijing, China

出　　处：《Asian Journal of Andrology》2014年第2期305-308,I0011,I0012,共6页亚洲男性学杂志（英文版）

基　　金：Financial support from the National Natural Science Foundation （81071279, 8100019） and the National Technology Support Plan （2009BAI 86B05） is gratefully acknowledged. We are grateful to be licensed for the use of Continuity 6.3b software from National Biomedical Computation Resources （National Institutes of Health Grant P41-RR-08605）, Cardiac Mechanics Research Group, University of California, San Diego, USA.

摘　　要：We investigated the prostate elasticity displayed by elastography and its correlation with the content and distribution of collagen type I （Col1） and type III （Col3）. A total of 62 patients underwent transrectal real-time tissue elastography （TRTE） examinations, Targeted biopsies were performed after 12-core systematic biopsy, The tissues corresponding to the elastograms were stained with picric acid-sirius red. The distribution of Col I and type Col3 was observed, and the collagen volume fraction （CVF） of these two types of collagen fibers was calculated, The CVFs of Coll in the stiff and soft groups were 0.05 ± 0.02 and 0.02 ± 0.01 {P= 0.002）, respectively. The CVFs of Col3 in the stiff and soft groups were 0.05 ± 0.04 and 0.07 ± 0,03 （P= 0,13）, respectively, The circular analysis results showed that collagen fibers were disorganized both in the soft and stiff groups, Coll and Col3 were mainly cross-linked, and some parallelization was observed in the sections. The distributions of Coll and Col3 were different between the stiff and soft groups （P = 0,03）, In conclusion, the texture of the prostate is due to the content of Coll and its relative correlation with Col3.We investigated the prostate elasticity displayed by elastography and its correlation with the content and distribution of collagen type I （Col1） and type III （Col3）. A total of 62 patients underwent transrectal real-time tissue elastography （TRTE） examinations, Targeted biopsies were performed after 12-core systematic biopsy, The tissues corresponding to the elastograms were stained with picric acid-sirius red. The distribution of Col I and type Col3 was observed, and the collagen volume fraction （CVF） of these two types of collagen fibers was calculated, The CVFs of Coll in the stiff and soft groups were 0.05 ± 0.02 and 0.02 ± 0.01 {P= 0.002）, respectively. The CVFs of Col3 in the stiff and soft groups were 0.05 ± 0.04 and 0.07 ± 0,03 （P= 0,13）, respectively, The circular analysis results showed that collagen fibers were disorganized both in the soft and stiff groups, Coll and Col3 were mainly cross-linked, and some parallelization was observed in the sections. The distributions of Coll and Col3 were different between the stiff and soft groups （P = 0,03）, In conclusion, the texture of the prostate is due to the content of Coll and its relative correlation with Col3.

关 键 词：ELASTOGRAPHY extracellular matrix LESION PROSTATE ultrasound 

分 类 号：R[医药卫生]